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Título: The renal effects and initial characterization of venom fromPhilodryas nattereri Steindachner, 1870
Autor(es): Nery, Marinetes Dantas de Aquino
Alves, Natacha Teresa Queiroz
Alves, Renata de Souza
Sousa, Daniel Freire de
Menezes, Dalgimar Beserra de
Nery, Erik de Aquino
Aquino, Hermano Damasceno de
Ribeiro, Rayane de Tasso Moreira
Monteiro, Helena Serra Azul
Palavras-chave: Insuficiência Renal
Mordeduras de Serpentes
Data do documento: 2014
Editor: Toxicology Reports
Citação: NERY, M. D. A. ; ALVES, N. T. Q. ; ALVES, R. S. ; SOUSA, D. F. ; MENEZES, D. B. ; NERY, E. A. ; AQUINO, H. D. ; RIBEIRO, R. T. M. ; MONTEIRO, H. S. A. (2014)
Abstract: The venom of the snake Philodryas nattereri is a mixture of proteins and toxic peptides withseveral important local and systemic actions, which are similar to those occurring in Both-rops snake bites. The mechanisms involved in the local and systemic actions of this venomare unknown. The aims of the work were to initial characterization of P. nattereri venomand investigate the effects of the poison in the renal perfusion system and in cultured renaltubular cells of the type MDCK (Madin–Darby canine kidney). The P. nattereri venom iscomposed majority of proteins (86.3%) and this poison promoted changes in all the evalu-ated renal parameters, mainly decreasing renal perfusion pressure (PP) and renal vascularresistance (RVR) and increasing urine flow (UF) and glomerular filtration rate (GFR). Themost relevant result was that this venom was highly detrimental to the renal tubules inde-pendent of the PP reduction, which was shown by a decrease in sodium (Na+), potassium(K+) and chloride (Cl−) electrolyte transport in the studied concentrations. The glomeruliand tubules contain protein bodies and blood extravasation, which were observed by his-tological analysis. The venom of P. nattereri reduced viability of the MDCK cells only at highconcentrations (50 and 100 g/mL) with an IC50of 169.5 g/mL.
Descrição: NERY, Marinetes Dantas de Aquino ; ALVES, Natacha Teresa Queiroz ; ALVES, Renata de Souza ; SOUSA, Daniel Freire de ; MENEZES, Dalgimar Beserra de ; NERY, Erik de Aquino ; AQUINO, Hermano Damasceno de ; RIBEIRO, Rayane de Tasso Moreira ; MONTEIRO, Helena Serra Azul. The renal effects and initial characterization of venom from Philodryas nattereri Steindachner, 1870. Toxicology Reports, v. 1, p. 812-819, 2014.
ISSN: 2214-7500
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