Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/10142
Título: In vitro effect of antibiotics on biofilm formation by Bacteroides fragilis group strains isolated from intestinal microbiota of dogs and their antimicrobial susceptibility
Autor(es): Silva, Janice Oliveira
Reis, Ana Catarina Martins
Quesada-Gómez, Carlos
Pinheiro, Adriana Queiroz
Freire, Rosemary Souza
Oriá, Reinaldo Barreto
Carvalho, Cibele Barreto Mano de
Palavras-chave: Bacteroides fragilis
Biofilmes
Microbiota
Data do documento: Ago-2014
Editor: Anaerobe
Citação: SILVA, J. O. ; REIS, A. C. M. ; QUESADA-GÓMEZ, C. ; PINHEIRO, A. Q. ; FREIRE, R. S. ; ORIÁ, R. B. ; CARVALHO, C. B. M. (2014)
Abstract: The Bacteroides fragilis group strains colonize the intestinal tract of dogs as commensal bacteria. Nevertheless, they can be opportunistic pathogens responsible for significant morbidity and mortality rates in dogs, like in oral infections, abscesses and wound infections. The purpose of this study was to evaluate antimicrobial susceptibility in B. fragilis strains isolated from dogs intestinal microbiota and to evaluate the effect of subinhibitory concentrations of some antimicrobials on biofilm formation. A total of 30 B. fragilis group strains were tested for susceptibility to ten antimicrobial agents by broth microdilution method. Thirteen B. fragilis strains were tested for biofilm formation and the biofilm producer strains were chosen to evaluate the effect of subinhibitory concentrations of six antimicrobials on biofilm formation. The isolates were susceptible to amoxicillin-clavulanic acid, metronidazole, imipenem and chloramphenicol. Tetracycline and clindamycin were active against 50% and 33% of the strains, respectively. When biofilm-forming strains were grown in the presence of sub-MICs of imipenem and metronidazole, the inhibition of biofilm formation was observed. In contrast, enrofloxacin at ½ MIC caused a significant increase in biofilm formation in two of four strains examined. In conclusion, the B. fragilis group strains isolated were susceptible to most of the antimicrobials tested and the sub-MIC concentrations of imipenem, metronidazole and clindamycin were able to inhibit the biofilm formation.
Descrição: SILVA, Janice Oliveira ; REIS, Ana Catarina Martins ; QUESADA-GÓMEZ, Carlos ; PINHEIRO, Adriana Queiroz ; FREIRE, Rosemary Souza ; ORIÁ, Reinaldo Barreto ; CARVALHO, Cibele Barreto Mano de. In vitro effect of antibiotics on biofilm formation by Bacteroides fragilis group strains isolated from intestinal microbiota of dogs and their antimicrobial susceptibility. Anaerobe, v. 28, p. 24-28, ago. 2014.
URI: http://www.repositorio.ufc.br/handle/riufc/10142
ISSN: 1075-9964
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