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dc.contributor.authorAbdon, Ana Paula Vasconcellos-
dc.contributor.authorVasconcelos, Renata Prado-
dc.contributor.authorCastro, Carolina Araújo-
dc.contributor.authorGuedes, Marjorie Moreira-
dc.contributor.authorTomé, Adriana da Rocha-
dc.contributor.authorCardoso, André Luiz Herzog-
dc.contributor.authorSantiago, Thiago de Melo-
dc.contributor.authorRebêlo, Luciana Magalhães-
dc.contributor.authorMoreira, Renato de Azevedo-
dc.contributor.authorMonteiro-Moreira, Ana Cristina de Oliveira-
dc.contributor.authorCampos, Adriana Rolim-
dc.date.accessioned2014-12-17T14:19:46Z-
dc.date.available2014-12-17T14:19:46Z-
dc.date.issued2014-08-
dc.identifier.citationABDON, A. P. V. et al. Ethanol-induced gastric injury : microscopic analysis of the protective effect of frutalin. International Journal of Peptide Research and Therapeutics, v. 20, n. 3, p. 325-332, ago. 2014.pt_BR
dc.identifier.issn1573-3904 (electronic version)-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/10304-
dc.description.abstractObtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanolinduced gastric injury. The gastroprotective effect of frutalina was evaluated using a murine model of ethanol-induced gastric injury. Damage of the gastric mucosa was assessed morphologically by light, scanning electron and atomic force microscopy. Lymphocyte infiltration, necrosis, disruption of the mucosal structures and epithelial desquamation were observed in the control group. In the group pretreated with frutalina at 0.5 mg/kg, gastroprotection, reduced tissue damage and preserved submucosal and mucosal structures were observed. In conclusion, FTL displayed gastroprotective activity against ethanol-induced gastric injury, preventing the formation of gastric ulcer and reducing epithelial desquamation, glandular damage, mucosal necrosis and infiltration. The observed effects appear to be due to mechanisms previously described for frutalin.pt_BR
dc.language.isoenpt_BR
dc.publisherInternational Journal of Peptide Research and Therapeuticspt_BR
dc.subjectArtocarpuspt_BR
dc.subjectEtanolpt_BR
dc.titleEthanol-induced gastric injury : microscopic analysis of the protective effect of frutalinpt_BR
dc.typeArtigo de Periódicopt_BR
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