Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/10826
Título: Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil
Autor(es): Jorge, Roberta Jeane B.
Monteiro, Helena S.A.
Gonçalves-Machado, Larissa
Guarnieri, Míriam C.
Ximenes, Rafael M.
Borges-Nojosa, Diva M.
Luna, Karla P. de O.
Zingali, Russolina B.
Corrêa-Netto, Carlos
Gutiérrez, José María
Sanz, Libia
Calvete, Juan J.
Pla, Davinia
Palavras-chave: Venenos
Bothrops
Mordeduras de Serpentes
Data do documento: Jan-2015
Editor: Journal of Proteomics
Citação: JORGE, R. J. B. ; MONTEIRO, H. S. A. ; GONÇALVES-MACHADO, L. ; GUARNIERE, M. C. ; XIMENES, R. M. ; BORGES-NOJOSA, D. M. ; LUNA, K. P. O. ; ZINGALI, R. B. ; CORRÊA-NETTO, C. ; GUTIÉRREZ, J. M. ; SANZ, L. ; CALVETE, J. J. ; PLA, D. (2015)
Abstract: The Caatinga lancehead, Bothrops erythromelas, is a medically relevant species, responsible for most of the snakebite accidents in most parts of its distribution range in northeastern Brazil. The spectrum and geographic variability of its venom toxins were investigated applying a venomics approach to venom pools from five geographic areas within the Caatinga ecoregion. Despite its wide habitat, populations of B. erythromelas from Ceará, Pernambuco, Juazeiro, Paraiba, and Ilha de Itaparica exhibit highly conserved venom proteomes. Mirroring their compositional conservation, the five geographic venom pools also showed qualitatively and quantitatively overlapping antivenomic profiles against antivenoms generated in Vital Brazil (BR) and Clodomiro Picado (CR) Institutes, using different venoms in the immunization mixtures. The paraspecificity exhibited by the Brazilian SAB and the Costa Rican BCL antivenoms against venom toxins from B. erythromelas indicates large immunoreactive epitope conservation across genus Bothrops during the last ~14 million years, thus offering promise for the possibility of generating a broad-spectrum bothropic antivenom.
Descrição: JORGE, Roberta Jeane B. ; MONTEIRO, Helena S.A. ; GONÇALVES-MACGADO, Larissa ; GUARNIERE, Míriam C. ; XIMENES, Rafael M. ; BORGES-NOJOSA, Diva M. ; LUNA, Karla P. de O. ; ZINGALI, Russolina B. ; CORRÊA-NETTO, Carlos ; GUTIÉRREZ, José María ; SANZ, Libia ; CALVETE, Juan J. ; PLA, Davinia. Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil. Journal of Proteomics, v. 114, p. 93-114, jan. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/10826
ISSN: 1874-3919
Aparece nas coleções:DFIFA - Artigos publicados em revista científica

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
2015_art_rmximenes.pdf1,72 MBAdobe PDFVisualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.