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dc.contributor.authorBarbosa, Orivaldo Alves-
dc.contributor.authorMacedo, Andre Luis Coutinho de Araujo-
dc.contributor.authorGuimarães, Manoel Pedro Guedes-
dc.contributor.authorTeixeira, Andre Costa-
dc.contributor.authorCavalcante, Raissa Marques-
dc.contributor.authorEvangelista, Priscila Dourado-
dc.contributor.authorSilva, Herivaldo Ferreira da-
dc.contributor.authorCorreia, Jose Walter-
dc.identifier.citationBARBOSA, O. A. et al. Thrombotic microangiopathy mediated by complement in postpartum sequentially treated with plasmapheresis and eculizumab. Journal of Hematology, v. 4, n. 2, p. 178-180, 2015.pt_BR
dc.identifier.issn1927-1212 Impresso-
dc.identifier.uri1927-1220 On line-
dc.description.abstractThe complement-mediated thrombotic microangiopathy (TMA), also known as atypical hemolytic uremic syndrome (aHUS), is rare and potentially fatal, presenting as TMA and dysfunction/endothe - lial edema secondary to diffuse disruption of a fluid phase alternat - ing complementary pathways. We report a case of a young woman with postpartum anuric renal failure, TMA and normal levels of AD- AMTS13 with partial clinical improvement after plasmapheresis, in which treatment with eculizumab led to the complete reversal of the clinical manifestations. Our work includes a brief literature review on the diagnosis and management of TMA in puerperium. mor cells; small vessel vasculitis, autoimmune or infectious etiology; endothelial dysfunction, which may be mediated by complement or Shiga-like toxin [1]. The period of pregnancy and postpartum eventually com- plicates these conditions, by immunological changes (predis- posing the formation of autoantibodies), changes in clotting factors with decreased level of ADAMST13 enzyme, which cleaves factor multimers of von Willebrand, and own pregnan- cy (preeclampsia and clinical spectra). Most of the time, the differential diagnosis of these diseases is difficult, requiring a multidisciplinary approach for the best outcome of the patient. We report a case of a young postpartum, with hypertensive disorders of pregnancy, with TMA initially conducted as TTP, with partial response to plasmapheresis and complete response to eculizumab.pt_BR
dc.publisherJournal of Hematologypt_BR
dc.subjectSíndrome Hemolítico-Urêmicapt_BR
dc.titleThrombotic microangiopathy mediated by complement in postpartum sequentially treated With plasmapheresis and eculizumabpt_BR
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