Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/16948
Título: Riparin A, a compound from Aniba riparia , attenuate the inflammatory response by modulation of neutrophil migration
Autor(es): Silva, Renan O.
Damasceno, Samara R. B.
Silva, Irismara S.
Silva, Valdelânia G.
Brito, Camila F. C.
Teixeira, Antônio Éder A.
Nunes, Geandra B. L.
Camara, Celso A.
B. Filho, José Maria
Gutierrez, Stanley J. C.
Ribeiro, Ronaldo A.
Souza, Marcellus H. L. P.
Barbosa, André L.R.
Freitas, Rivelilson M.
Medeiros, Jand Venes R.
Palavras-chave: Estresse oxidativo
Neutrófilos
Data do documento: Mar-2015
Citação: SILVA, R. O. ; DAMASCENO, S. R. B. ; SILVA, I. S. ; SILVA, V. G. ; BRITO, C. F. C. ; TEIXEIRA, A. É. A. ; NUNES, G. B. L. ; CAMARA, C. A. ; B. FILHO, J. M. ; GUTIERREZ, S. J.C. ; RIBEIRO, R. A. ; SOUZA, M. H. L. P. ; BARBOSA, A. L. R. ; FREITAS, R. M. ; MEDEIROS, J. V. R. (2015)
Abstract: Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia , has been shown to have anti- oxidant activity and cytotoxicity in vitro . This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobar- bituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor- a and interleukin-1 b ) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.
Descrição: SILVA, Renan O. ; DAMASCENO, Samara R. B. ; SILVA, Irismara S. ; SILVA, Valdelânia G. ; BRITO, Camila F. C. ; TEIXEIRA, Antônio Éder A. ; NUNES, Geandra B. L. ; CAMARA, Celso A. ; B. FILHO, José Maria ; GUTIERREZ, Stanley J. C. ; RIBEIRO, Ronaldo A. ; SOUZA, Marcellus H. L. P. ; BARBOSA, André L. R. ; FRIETAS, Rivelilson M. ; MEDEIROS, Jand Venes R. Riparin A, a compound from Aniba riparia , attenuate the inflammatory response by modulation of neutrophil migration. Chemico-Biological Interactions, Limerick, Irlanda, v. 229, p. 55-63, mar. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/16948
ISSN: 0009-2797
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