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Título: Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines
Autor(es): Ralph, Ana Carolina Lima
Calcagno, Danielle Queiroz
Souza, Luciana Gregório da Silva
Lemos, Telma Leda Gomes de
Montenegro, Raquel Carvalho
Smith, Marília de Arruda Cardoso
Vasconcellos, Marne Carvalho de
Palavras-chave: Melanoma
Data do documento: Ago-2016
Editor: Toxicology in Vitro
Citação: RALPH, A. C. L. ; CALCAGNO, D. Q. ; SOUZA, L. G. S. ; LEMOS, T. L. G. ; MONTENEGRO, R. C. ; SMITH, M. A. C. ; VASCONCELLOS, M. C. (2016)
Abstract: Cancer is a public health problem and the second leading cause of death worldwide. The incidence of cutaneous melanoma has been notably increasing, resulting in high aggressiveness and poor survival rates. Taking into account the antitumor activity of biflorin, a substance isolated from Capraria biflora L. roots that is cytotoxic in vitro and in vivo, this study aimed to demonstrate the action of biflorin against three established human melanoma cell lines that recapitulate the molecular landscape of the disease in terms of genetic alterations and mutations, such as the TP53, NRAS and BRAF genes. The results presented here indicate that biflorin reduces the viability of melanoma cell lines by DNA interactions. Biflorin causes single and double DNA strand breaks, consequently inhibiting cell cycle progression, replication and DNA repair and promoting apoptosis. Our data suggest that biflorin could be considered as a future therapeutic option for managing melanoma.
Descrição: RALPH, Ana Carolina Lima ; CALCAGNO, Danielle Queiroz ; SOUZA, Luciana Gregório da Silva ; LEMOS, Telma Leda Gomes de ; MONTENEGRO, Raquel Carvalho ; SMITH, Marília de Arruda Cardoso ; VASCONCELLOS, Marne Carvalho de. Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines. Toxicology in Vitro, New York, v. 34, p. 237-245, aug. 2016.
ISSN: 0887-2333
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