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|Título:||A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars|
Silva, P.G. de B.
|Data do documento:||Set-2016|
|Editor:||International Journal of Oral and Maxillofacial Surgery|
|Citação:||COSTA, F. W. G. ; SOARES, E. C. S. ; ESSES, D. F. S. ; SILVA, P. G. B. ; BEZERRA, T. P. ; SCARPARO, H. C. ; RIBEIRO, T. R. ; FONTELES, C. S. R. (2015)|
|Abstract:||Pain after third molar extraction has been considered the most suitable pharmaceutical model to evaluate acute pain. This study aimed to evaluate the pre-emptive analgesic/anti-inflammatory efficacy of etoricoxib 120 mg following mandibular third molar surgery. A split-mouth, randomized, triple-blind, placebo-controlled study was conducted with patients undergoing the surgical removal of mandibular third molars. All volunteers were allocated randomly to receive either etoricoxib 120 mg or placebo 1 h preoperatively, and inflammatory events were evaluated. An estimated sample of 18 surgical units per group was required based on a pilot study (95% confidence level and 80% statistical power). Rescue medication was analyzed by Kaplan–Meier method through log-rank Mantel–Cox test and Pearson linear correlation (P < 0.05). Pre-emptive etoricoxib reduced postoperative pain scores significantly in comparison to placebo (P < 0.001), with a pain score peak at 6 h after surgery (P < 0.001). The mean rescue medication consumption was lower in the etoricoxib group compared to the placebo group over the study period (P < 0.05). There was no statistically significant difference between groups related to swelling and trismus. The pre-emptive administration of etoricoxib 120 mg significantly reduced the postoperative pain intensity and the need for rescue medication, but did not reduce swelling or trismus.|
|Descrição:||COSTA, F.W.G. ; SOARES, E.C.S. ; ESSES, D.F.S. ; SILVA, P.G. de B. ; BEZERRA, T.P. ; SCARPARO, H.C. ; RIBEIRO, T.R. ; FONTELES, C.S.R. A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars. International Journal of Oral and Maxillofacial Surgery, Copenhagen, v. 44, n. 9, p. 1166-1174, sep. 2015.|
|Aparece nas coleções:||DCOD - Artigos publicados em revistas científicas|
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