Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/17794
Título: A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars
Autor(es): Costa, F.W.G.
Soares, E.C.S.
Esses, D.F.S.
Silva, P.G. de B.
Bezerra, T.P.
Scarparo, H.C.
Ribeiro, T.R.
Fonteles, C.S.R.
Palavras-chave: Dente Serotino
Dor Aguda
Data do documento: Set-2016
Editor: International Journal of Oral and Maxillofacial Surgery
Citação: COSTA, F. W. G. ; SOARES, E. C. S. ; ESSES, D. F. S. ; SILVA, P. G. B. ; BEZERRA, T. P. ; SCARPARO, H. C. ; RIBEIRO, T. R. ; FONTELES, C. S. R. (2015)
Abstract: Pain after third molar extraction has been considered the most suitable pharmaceutical model to evaluate acute pain. This study aimed to evaluate the pre-emptive analgesic/anti-inflammatory efficacy of etoricoxib 120 mg following mandibular third molar surgery. A split-mouth, randomized, triple-blind, placebo-controlled study was conducted with patients undergoing the surgical removal of mandibular third molars. All volunteers were allocated randomly to receive either etoricoxib 120 mg or placebo 1 h preoperatively, and inflammatory events were evaluated. An estimated sample of 18 surgical units per group was required based on a pilot study (95% confidence level and 80% statistical power). Rescue medication was analyzed by Kaplan–Meier method through log-rank Mantel–Cox test and Pearson linear correlation (P < 0.05). Pre-emptive etoricoxib reduced postoperative pain scores significantly in comparison to placebo (P < 0.001), with a pain score peak at 6 h after surgery (P < 0.001). The mean rescue medication consumption was lower in the etoricoxib group compared to the placebo group over the study period (P < 0.05). There was no statistically significant difference between groups related to swelling and trismus. The pre-emptive administration of etoricoxib 120 mg significantly reduced the postoperative pain intensity and the need for rescue medication, but did not reduce swelling or trismus.
Descrição: COSTA, F.W.G. ; SOARES, E.C.S. ; ESSES, D.F.S. ; SILVA, P.G. de B. ; BEZERRA, T.P. ; SCARPARO, H.C. ; RIBEIRO, T.R. ; FONTELES, C.S.R. A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars. International Journal of Oral and Maxillofacial Surgery, Copenhagen, v. 44, n. 9, p. 1166-1174, sep. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/17794
ISSN: 0901-5027
Aparece nas coleções:DCOD - Artigos publicados em revistas científicas

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
2015_art_fwgcosta.pdf995,49 kBAdobe PDFVisualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.