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|Título:||In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts|
|Autor(es):||Dória, Grace Anne A.|
Menezes, Paula P.
Lima, Bruno S.
Vasconcelos, Bruno S.
Silva, Francilene A.
Henriques, Raíssa M.
Melo, Marcélia G. D.
Alves, Ângela V. F.
Moraes, Manoel O.
Pessoa, Cláudia Ó
Carvalho, Adriana A. C
Prata, Ana Paula N.
A. Junior, Ricardo Luiz C.
Lima-Verde, Isabel B.
Quintans-Júnior, Lucindo J.
Bezerra, Daniel P.
Nogueira, Paulo C. L.
Araujo, Adriano A. S.
|Data do documento:||Ago-2016|
|Citação:||DÓRIA, G. A. A. ; MENEZES, P. P. ; LIMA, B. S. ; VASCONCELOS, B. S. ; SILVA, F. A. ; HENRIQUES, R. M. ; MELO, M. G. D. ; ALVES, Â. V. F. ; MORAES, M. O. ; PESSOA, C. Ó ; CARVALHO, A. A. ; PRATA, A. P. N. ; A. JUNIOR, R. L. C. ; LIMA-VERDE, I. B. ; QUINTANS-JÚNIOR, L. J. ; BEZERRA, D. P. ; NOGUEIRA, P. C. L. ; ARAÚJO, A. A. S. (2016)|
|Abstract:||Background: Remirea maritima has been widely used in the treatment of diarrhea, kidney disease, and high fever and for therapeutic purposes, such as an analgesic and anti-inﬂammatory. However, few sci entiﬁc research studies on its medicinal properties have been reported. Purpose: The present study aimed to investigate the anticancer potential of aqueous extract (AE), 40% hydroalcoholic extracts (40HA) and 70% (70HA) from R. maritima in experimental models and to identify its phytochemical compounds. Methods: The chemical composition of AE, 40HA and 70HA was assessed by HPLC-DAD and ESI-IT-MS/MS . In vitro activity was determined on cultured tumor cell, NCI-H385N (Broncho-alveolar carcinoma), OVCAR 8 (Ovarian carcinoma) and PC-3 M (prostate carcinoma) by the MTT assay, and the in vivo antitumor activity was assessed in Sarcoma 180-bearing mice. Toxicological parameters were also evaluated as well as the humoral immune response. Results: Among the aqueous and hydroalcoholic extracts of R. maritima , only 40HA showed in vitro bi ological effect potential, presenting IC 50 values of 27.08, 46.62 and > 50 μg/ml for OVCAR-8, NCI-H385M and PC-3 M cells lines, respectively. Regarding chemical composition, a mixture of isovitexin-2 O β-D glucopyranoside, vitexin-2 O β-D-glucopyranoside, luteolin-7 O -glucuronide and 1 O -(E)-caffeoyl β-D glucose were identiﬁed as the major phytochemical compounds of the extracts. In the in vivo study, the tumor inhibition rates were 57.16–62.57% at doses of 25 mg/kg and 50 mg/kg, respectively, and the tu mor morphology presented increasing numbers of apoptotic cells. Additionally, 40HA also demonstrated signiﬁcantly increased of OVA-speciﬁc total Ig. Conclusions: 40HA exhibited in vitro and in vivo anticancer properties without substantial toxicity that could be associated with its immunostimulating properties.|
|Descrição:||DÓRIA, Grace Anne A. et al. In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts. Phytomedicine, Stuttgart, v. 23, n. 9, p. 914-922, aug. 2016.|
|Aparece nas coleções:||DFIFA - Artigos publicados em revista científica|
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