Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19115
Título: Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice
Autor(es): Lima, Eliane Brito Cortez
Sousa, Caren Nádia Soares de
Vasconcelos, Germana Silva
Meneses, Lucas Nascimento
Pereira, Yuri Freitas e Silva
Ximenes, Naiara Coelho
Santos Júnior, Manuel Alves
Matos, Natália Castelo Branco
Brito, Rayanne
Miron, Diogo
Leal, Luzia Kalyne Almeida Moreira
Macêdo, Danielle
Vasconcelos, Silvânia Maria Mendes
Palavras-chave: Estresse Oxidativo
Oxidative Stress
Fenóis
Phenols
Data do documento: Jul-2016
Editor: Natural Medicines
Citação: LIMA, E. B. C. ; SOUSA, C. N. S. ; VASCONCELOS, G. S. ; MENESES, L. N. ; PEREIRA, Y. F. S. ; XIMENES, N. C. ; SANTOS JÚNIOR, M. A. ; MATOS, N. C. B; ; BRITO, R. ; MIRON, D. ; LEAL, L. K. A. M. ; MACÊDO, D. ; VASCONCELOS, S. M. M. (2016)
Abstract: The plant Cocos nucifera and its derivatives have shown antidepressant-like effects, although its hydroalcoholic extract has not been studied with this end in mind. Therefore, we decided to determine the antidepres- sant-like effects of the standardized hydroalcoholic extract of Cocos nucifera husk fiber (HECN) as well as oxidative alterations in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST), and the levels of brain-derived neurotrophic factor (BDNF) in the HC of mice. The extract was characterized based on the content of total polyphenols as well as two phenol compounds—catechin and chloro- genic acid—by HPLC-PDA. Male animals were treated per os (p.o.) for 7 days with distilled water or HECN (50, 100 or 200 mg/kg), or intraperitoneally with vitamin E (Vit E 400 mg/kg). One hour after the last drug administration, the animals were submitted to the open field test, forced swimming test (FST), tail suspension test (TST) and, immediately after the behavioral tests, had their brain removed for neurochemical determinations. The results showed that HECN100 decreased the immobility time in the FST and TST presenting, thus demonstrating an antidepressant-like effect. The administration of HECN decreased malondialdehyde levels in all doses and brain areas studied with the exception of HECN50 in the HC. The administration of HECN also decreased nitrite levels in all doses and brain regions studied. HECN100 also increased the levels of BDNF in HC of mice. In conclusion, we demonstrated that HECN has antidepressant-like properties, probably based on its antioxidant and
Descrição: LIMA, Eliane Brito Cortez et al. Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice. Natural Medicines, Tokyo, v. 70, n. 3, p. 510–521, jul., 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/19115
ISSN: 1340-3443
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