Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19148
Título: Red propolis ameliorates ischemic-reperfusion acute kidney injury
Autor(es): Costa, Marcus Felipe Bezerra da
Libório, Alexandre Braga
Teles, Flávio
Martins, Conceição da Silva
Soares, Pedro Marcos Gomes
Meneses, Gdayllon C.
Rodrigues, Francisco Adelvane de Paulo
Leal, Luzia Kalyne Almeida Moreira
Miron, Diogo
Silva, Aline Holanda
Martins, Alice Maria Costa
Palavras-chave: Lesão Renal Aguda
Acute Kidney Injury
Própole
Data do documento: Ago-2015
Editor: Phytomedicine
Citação: COSTA, M. F. B. ; LIBÓRIO, A. B. ; TELES, F. ; MARTINS, C. S. ; SOARES, P. M. G. ; MENESES, G. C. ; RODRIGUES, F. A. P. ; LEAL, L. K. A. M. ; MIRON, D. ; SILVA, A. H. ; MARTINS, A. M. C. (2015)
Abstract: Introduction: Acute kidney injury (AKI) remains a great problem in clinical practice. Renal ischemia/reperfusion(I/R)injuryisacomplexpathophysiologicalprocess.Propolisisanaturalpolyphenol-rich resinous substance collected by honeybees from a variety of plant sources that has anti-inflammatory and anti-oxidative properties. Red propolis (RP) protection in renal I/R injury was investigated. Methods: Male Wistar rats underwent unilateral nephrectomy and contralateral renal I/R (60 min). Rats were divided into four groups: (1) sham group, (2) RP group (sham-operated rats treated with RP), 3) IR group (rats submitted to ischemia) and (4) IR-RP (rats treated with RP before ischemia). At 48 h after reperfusion, renal function was assessed and kidneys were removed for analysis. Results: I/Rincreasedplasmalevelsofcreatinineandreducedcreatinineclearance(CrCl),andRPprovidedprotection against this renal injury. Red propolis significantly improves oxidative stress parameters when compared with the IR group. Semiquantitative assessment of the histological lesions showed marked structural damage in I/R rats compared with the IR-RP rats. RP attenuates I/R-induced endothelial nitric oxide-synthase down regulation and increased heme-oxygenase expression in renal tissue. Conclusion: Red propolis protects kidney against acute ischemic renal failure and this protection is associated with reduced oxidative stress and eNOS and heme-oxygenase up regulation.
Descrição: COSTA, Marcus Felipe Bezerra da et al. Red propolis ameliorates ischemic-reperfusion acute kidney injury. Phytomedicine, Stuttgart, v. 22, n. 9, 1, p. 787–795, aug. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/19148
ISSN: Impresso 0944-7113
On-line 1618-095X
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