Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19158
Título: Rosmarinic acid prevents against memory deficits in ischemic mice
Autor(es): Fonteles, Analu Aragão
Souza, Carolina Melo de
Neves, Julliana Catharina de Sousa
Menezes, Ana Paula Fontenele
Carmo, Marta Regina Santos do
Fernandes, Francisco Diego Pinheiro
Araújo, Patrícia Rodrigues de
Andrade, Geanne Matos de
Palavras-chave: Isquemia Encefálica
Brain Ischemia
Polifenóis
Polyphenols
Data do documento: Jan-2016
Editor: Behavioural Brain Research
Citação: FONTELES, A. A. ; SOUZA, C. M. ; NEVES, J. C. S. ; MENEZES, A. P. F. ; CARMO, M. R. S. ; FERNANDES, F. D. P. ; ARAÚJO, P. R. ; ANDRADE, G. M. (2016)
Abstract: Polyphenols have neuroprotective effects after brain ischemia. It has been demonstrated that rosmarinic acid (RA), a natural phenolic compound, possesses antioxidant and anti-inflammatory properties. To evaluate the effectiveness of RA against memory deficits induced by permanent middle cerebral artery occlusion (pMCAO) mice were treated with RA (0.1, 1, and 20 mg/kg/day, i.p. before ischemia and during 5 days). Animals were evaluated for locomotor activity and working memory 72 h after pMCAO, and spatial and recognition memories 96 h after pMCAO. In addition, in another set of experiments brain infarction, neurological deficit score and myeloperoxidase (MPO) activity were evaluates 24 h after the pMCAO. Finally, immunohistochemistry, and western blot, and ELISA assay were used to analyze glial fibrillary acidic protein (GFAP), and synaptophysin (SYP) expression, and BDNF level, respectively. The working, spatial, and recognition memory deficits were significantly improved with RA treatment (20 mg/kg). RA reduced infarct size and neurological deficits caused by acute ischemia. The mechanism for RA neuroprotection involved, neuronal loss suppression, and increase of synaptophysin expression, and increase of BDNF. Furthermore, the increase of MPO activity and GFAP immunireactivity were prevented in MCAO group treated with RA. These results suggest that RA exerts memory protective effects probably due to synaptogenic activity and anti-inflammatory action.
Descrição: FONTELES, Analu Aragão et al. Rosmarinic acid prevents against memory deficits in ischemic mice. Behavioural Brain Research, v. 297, p. 91–103, jan., 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/19158
ISSN: 0166-4328
1872-7549
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