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Título: Neuroinflammatory response to experimental stroke is inhibited by eriodictyol
Autor(es): Ferreira, Emerson de Oliveira
Fernandes, Mara Yone Soares Dias
Lima, Neila Maria Rocha de
Carmo, Marta Regina Santos do
Lima, Francisco Arnaldo Viana
Fonteles, Analu Aragão
Menezes, Ana Paula Fontenele
Andrade, Geanne Matos de
Neves, Kelly Rose Tavares
Palavras-chave: Flavonoides
Data do documento: Out-2016
Editor: Behavioural Brain Research
Citação: FERREIRA, E. O. ; FERNANDES, M. Y. S. D. ; LIMA, N. M. R. ; NEVES, K. R. T. ; CARMO, M. R. S. ; LIMA, F. A. V. ; FONTELES, A. A. ; MENEZES, A. P. F. ; ANDRADE, G. M. (2016)
Abstract: Background Cerebral ischemia is a common disease and one of the most common causes of death and disability worldwide. The lack of glucose and oxygen in neuronal tissue leads to a series of inflammatory events, culminating in neuronal death. Eriodictyol is a flavonoid isolated from the Chinese herb Dracocephalum rupestre that has been proven to have anti-inflammatory properties. Hypothesis/Purpose Thus, the present study was designed to explore whether eriodictyol has neuroprotective effects against the neuronal damage, motor and memory deficits induced by permanent middle cerebral artery occlusion (pMCAO) in mice. Study Design Animals were orally treated with eriodictyol (1, 2 and 4 mg/kg) or vehicle (saline) 30 min before pMCAO, 2 h after, and then once daily for the following five days. Methods The parameters studied were neuronal viability, brain infarcted area; sensorimotor deficits; exploratory activity; working and aversive memory; myeloperoxidase (MPO) activity; TNFα, iNOS and GFAP immunoreactivity. Results The treatment with eriodictyol prevented neuronal death, reduced infarct area and improved neurological and memory deficits induced by brain ischemia. The increase of MPO activity and TNF-α, iNOS and GFAP expression were also reduced by eriodictyol treatment. Conclusion These findings demonstrate that eriodictyol exhibit promising neuroprotection effects against the permanent focal ischemia cerebral injury in the mice experimental model and the underlying mechanisms might be mediated through inhibition of neuroinflammation.
Descrição: FERREIRA, Emerson de Oliveira et al. Neuroinflammatory response to experimental stroke is inhibited by eriodictyol. Behavioural Brain Research, Amsterdam, v. 312, p. 321–332, oct., 2016.
ISSN: 0166-4328
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