Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19210
Título: Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia
Autor(es): Alcântara, Glaura Fernandes Teixeira de
Simões-Neto, Eudes
Cruz, Giovany Michely Pinto da
Nobre, Maria Elizabeth Pereira
Neves, Kelly Rose Tavares
Andrade, Geanne Matos de
Brito, Gerly Anne de Castro
Viana, Glauce Socorro de Barros
Palavras-chave: Isquemia Encefálica
Curcumina
Curcumin
Data do documento: Fev-2016
Editor: Journal of Traditional and Complementary Medicine
Citação: ALCÂNTARA, G. F. T. ; SIMÕES-NETO, E. ; CRUZ, G. M. P. ; NOBRE, M. E. P. ; NEVES, K. R. T. ; ANDRADE, G. M. ; BRITO, G. A. C. ; VIANA, G. S. B. (2016)
Abstract: Curcumin, a curcuminoid from Curcuma longa, presents antioxidant and anti-inflammatory actions and, among pathological changes of cerebral ischemic injury, inflammation is an important one. The objectives were to study the neuroprotective action of curcumin, in a model of global ischemia. Male Wistar rats (sham-operated, ischemic untreated and ischemic treated with curcumin, 25 or 50 mg/kg, p.o.) were anesthesized and their carotid arteries occluded, for 30 min. The SO group had the same procedure, except for carotid occlusion. In the 1st protocol, animals were treated 1 h before ischemia and 24 h later; and in the 2nd protocol, treatments began 1 h before ischemia, continuing for 7 days. Twenty four hours after the last administration, animals were euthanized and measurements for striatal monoamines were performed, at the 1st and 7th days after ischemia, as well as histological and immunohistochemical assays in hippocampi. We showed in both protocols, depletions of DA and its metabolites (DOPAC and HVA), in the ischemic group, but these effects were reversed by curcumin. Additionally, a decrease seen in 5-HT contents, 1 day after ischemia, was also reversed by curcumin. This reversion was not seen 7 days later. On the other hand, a decrease observed in NE levels, at the 7th day, was totally reversed by curcumin. Furthermore, curcumin treatments increased neuronal viability and attenuated the immunoreactivity for COX-2 and TNF-alpha, in the hippocampus in both protocols. We showed that curcumin exerts neuroprotective actions, in a model of brain ischemia that are probably related to its anti-inflammatory activity.
Descrição: ALCÂNTARA, Glaura Fernandes Teixeira de et al. Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia. Journal of Traditional and Complementary Medicine, v. 1, p. 1-10., feb.,2016.
URI: http://www.repositorio.ufc.br/handle/riufc/19210
ISSN: 2225-4110
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