Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19270
Título: A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption
Autor(es): Costa, Cecília Leite
López-Ureña, Diana
Assis, Thiago de Oliveira
Ribeiro, Ronaldo A.
Silva, Rodrigo Otávio Silveira
Rupnik, Maja
Wilcoxi, Mark H.
Carvalho, Alex Fiorini de
Carmo, Anderson Oliveira do
Dias, Adriana Abalen Martins
Carvalho, Cibele Barreto Mano de
Chaves-Olarte, Esteban
Rodríguez, César
Quesada-Gómez, Carlos
Brito, Gerly Anne de Castro
Palavras-chave: Estresse Oxidativo
Oxidative Stress
Clostridium difficile
Data do documento: Ago-2016
Editor: Anaerobe
Citação: COSTA, C. L. ; LÓPEZ-UREÑA, D. ; ASSIS, T. O. ; RIBEIRO, R. A. ; SILVA, R. O. S. ; RUPNIKH, M. ; WILCOXI, M. H. ; CARVALHO, A. F. ; CARMO, A. O. ; DIAS, A. A. M. ; CARVALHO, C. B. M. ; CHAVES-OLARTE, E. ; RODRIGUEZ, C. ; QUESADA-GÓMEZ, C. ; BRITO, G. A. C. (2016)
Abstract: The epidemiology of Clostridium difficile infections is highly dynamic as new strains continue to emerge worldwide. Here we present a detailed analysis of a new C. difficile strain (ICC-45) recovered from a cancer patient in Brazil that died from severe diarrhea. A polyphasic approach assigned a new PCR-ribotype and PFGE macrorestriction pattern to strain ICC-45, which is toxigenic (tcdA+, tcdB+ and ctdB+) and classified as ST41 from MLST Clade 2 and toxinotype IXb. Strain ICC-45 encodes for a variant TcdB that induces a distinct CPE in agreement with its toxinotype. Unlike epidemic NAP1/027 strains, which are also classified to MLST Clade 2, strain ICC-45 is susceptible to fluoroquinolones and does not overproduce toxins TcdA and TcdB. However, supernatants from strain ICC-45 and a NAP1/027 strain produced similar expression of pro-inflammatory cytokines, epithelial damage, and oxidative stress response in the mouse ileal loop model. These results highlight inflammation and oxidative stress as common features in the pathogenesis of C. difficile Clade 2 strains. Finally, this work contributes to the description of differences in virulence among various C. difficile strains.
Descrição: COSTA, Cecília Leite et al. A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption. Anaerobe, London, v. 40, p. 76-84, aug. 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/19270
ISSN: 1075-9964
1095-8274
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