Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19299
Título: Antinociceptive and anti-inflammatory effects of Caryocar coriaceum Wittm fruit pulp fixed ethyl acetate extract on zymosan-induced arthritis in rats
Autor(es): Oliveira, Francisco Fábio Bezerra de
Araújo, Joana Cláudia Bezerra de
Pereira, Anamaria Falcão
Brito, Gerly Anne Castro
Gondim, Delane Viana
Ribeiro, Ronaldo de Albuquerque
Menezes, Irwin Rose Alencar de
Vale, Mariana Lima
Palavras-chave: Artrite
Zimosan
Zymosan
Nociceptividade
Data do documento: Nov-2015
Editor: Journal of Ethnopharmacology
Citação: OLIVEIRA, F. F. B. ; ARAÚJO, J. C. B. ; PEREIRA, A. F. ; BRITO, G. A. C. ; GONDIM, D. V. ; RIBEIRO, R. A. ; MENEZES, I. R. A. ; VALE, M. L. (2015)
Abstract: The ethyl acetate extract from the fruit pulp of Caryocar coriaceum Wittm (Caryocaraceae), popularly known as pequi, has wide applications in popular medicine. Preclinical tests have demonstrated the therapeutic properties of the oil. We investigated the antinociceptive and anti-inflammatory effects of Pequi C. coriaceum Wittm ethyl acetate extract (PCCO) on zymosan-induced arthritis in rat knee joint. The animals were pretreated with PCCO for 7 consecutive days or with a single dose. Paw elevation time (PET), leukocyte infiltration, myeloperoxidase activity (MPO) and cytokine levels were assessed 4 h after zymosan injection. Synovial tissue was harvested for immunohistochemical analysis, edema and vascular permeability. We observed a significant decrease in PET with PCCO pretreatment. PCCO showed a significant reduction of leukocyte migration and a decrease in MPO. Decreases were observed in cytokine release in the synovial fluid and TNF-α and cyclooxygenase-1 immunostaining in synovial tissue. Edema was inhibited by treatment with all doses of PCCO. The data suggest that PCCO exerts antinociceptive and anti-inflammatory effects on arthritis in rats.
Descrição: OLIVEIRA, Francisco Fábio Bezerra de et al. Antinociceptive and anti-inflammatory effects of Caryocar coriaceum Wittm fruit pulp fixed ethyl acetate extract on zymosan-induced arthritis in rats. Journal of Ethnopharmacology, Limerick, v. 174, p. 452–463, nov. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/19299
ISSN: 0378-8741
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