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|Título:||Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress|
|Autor(es):||Réus, Gislaine Z.|
Abelaira, Helena M.
Maciel, Amanda L.M
Santos, Maria Augusta B.dos
Carlessi, Anelise S.
Steckert, Amanda V.
Ferreira, Gabriela K.
Prá, Samira D. De
Streck, Emilio L.
Macêdo, Danielle S.
|Data do documento:||Abr-2015|
|Editor:||Metabolic Brain Disease|
|Citação:||RÉUS, G. Z. ; ABELAIRA, H. M. ; MACIEL, A. L. ; SANTOS, M. A. B. ; CARLESSI, A. S. ; STECKERT, A. V. ; FERREIRA, G. K. ; PRÁ, S. D. ; STRECK, E. L. ; MACÊDO, D. S. ; QUEVEDO, J. (2015)|
|Abstract:||Studies have been suggested that minocycline can be a potential new agent for the treatment of depression. In addition, both oxidative stress and energymetabolismpresent an important role in pathophysiology of depression. So, the presentstudywasaimedtoevaluatetheeffectsofminocycline on stress oxidative parameters and energy metabolism in the brainofadultratssubmittedtothechronicmildstressprotocol (CMS). After CMS Wistar, both stressed animals as controls received twice ICV injection of minocycline (160 μg) or vehicle. The oxidative stress and energy metabolism parameters were assessed in the prefrontal cortex (PF), hippocampus (HIP), amygdala (AMY) and nucleus accumbens (Nac). Our findings showed that stress induced an increase on protein carbonylinthePF,AMYandNAc,andmynociclineinjection reversed this alteration. The TBARS was increased by stress in the PF, HIP and NAc, however, minocycline reversed the alteration in the PF and HIP. The Complex I was incrased in AMYbystress,andminocyclinereversedthiseffect,however reducedComplexIactivityintheNAc;ComplexIIreducedin PF and AMY by stress or minocycline; the Complex II-III increased in the HIP in stress plus minocycline treatment and in the NAc with minocycline; in the PF and HIP there were a reduced in Complex IV with stress and minocycline. The creatine kinase was reduced in AMY and NAc with stress and minocycline. In conclusion, minocycline presented neuroprotector effects by reducing oxidative damage and regulating energy metabolism in specific brain areas.|
|Descrição:||RÉUS, Gislaine Z. et al. Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress. Metabolic Brain Disease, New York, v. 30, n. 2, p. 545-553, apr. 2015.|
|Aparece nas coleções:||DFIFA - Artigos publicados em revista científica|
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