Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19478
Título: GBR 12909 administration as an animal model of bipolar mania : time course of behavioral, brain oxidative alterations and effect of mood stabilizing drugs
Autor(es): Queiroz, Ana Isabelle G.
Araújo, Maíra Moraes de
Araújo, Tatiane da Silva
Souza, Greicy Coelho de
Cavalcante, Lígia Menezes
Machado, Michel de Jesus Souza
Lucena, David Freitas de
Quevedo, João
Macêdo, Danielle
Palavras-chave: Transtorno Bipolar
Bipolar Disorder
Polimorfismos
Data do documento: Out-2015
Editor: Metabolic Brain Disease
Citação: QUEIROZ, A. I. G. ; ARAÚJO, M. M. ; ARAÚJO, T. S. ; SOUZA, G. C. ; CAVALCANTE, L. M. ; MACHADO, M. J. S. ; LUCENA, D. F. ; QUEVEDO, J. ; MACÊDO, D. (2015)
Abstract: Polymorphisms in the human dopamine transporter (DAT) are associated with bipolar endophenotype. Based on this, the acute inhibition of DAT using GBR12909 causes behavioral alterations that are prevented by valproate (VAL), being related to a mania-like model. Herein our first aim was to analyze behavioral and brain oxidative alterations during a 24 h period post-GBR12909 to better characterize this model. Our second aim was to determine the preventive effects of lithium (Li) or VAL 2 h post-GBR12909. For this, adult male mice received GBR12909 or saline being evaluated at 2, 4, 8, 12 or 24 h post-administration. Hyperlocomotion, levels of reduced glutathione (GSH) and lipid peroxidation in brain areas were assessed at all these time-points. GBR12909 caused hyperlocomotion at 2 and 24 h. Rearing behavior increased only at 2 h. GSH levels decreased in the hippocampus and striatum at the time points of 2, 4, 8 and 12 h. Increased lipid peroxidation was detected at the time-points of 2 and 12 h in all brain areas studied. At the time-point of 2 h post-GBR12909 Li prevented the hyperlocomotion and rearing alterations, while VAL prevented only rearing alterations. Both drugs prevented pro-oxidative changes. In conclusion, we observed that the main behavioral and oxidative alterations took place at the time-period of 2 h post-GBR12909, what points to this time-period as the best for the assessment of alterations in this model. Furthermore, the present study expands the predictive validity of the model by the determination of the preventive effects of Li.
Descrição: QUEIROZ, Ana Isabelle G. et al. GBR 12909 administration as an animal model of bipolar mania : time course of behavioral, brain oxidative alterations and effect of mood stabilizing drugs. Metabolic Brain Disease, v. 30, n. 5, p. 1207-1215, oct. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/19478
ISSN: 0885-7490
1573-7365
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