Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19479
Título: Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine
Autor(es): Borella, Vládia Célia Moreira
Seeman, Mary V.
Cordeiro, Rafaela Carneiro
Santos, Júnia Vieira dos
Souza, Marcos Romário Matos de
Fernandes, Ethel Nunes de Sousa
Monte, Aline Santos
Vasconcelos, Silvânia Maria Mendes
Quinn, John P.
Lucena, David F. de
Carvalho, André F.
Macêdo, Danielle
Palavras-chave: Esquizofrenia
Estresse Oxidativo
Oxidative Stress
Data do documento: Mai-2016
Editor: Developmental Neurobiology
Citação: BORELLA, V. C. M. ; SEEMAN, M. V. ; CORDEIRO, R. C. ; SANTOS, J. V. ; SOUZA, M. R. M. ; FERNANDES, E. N. S. ; MONTE, A. S. ; VASCONCELOS, S. M. M. ; QUINN, J. P. ; LUCENA, D. F. ; CARVALHO, A. F. ; MACÊDO, D. (2016)
Abstract: Neonatal N-methyl-D-aspartate (NMDA) receptor blockade in rodents triggers schizophrenia (SCZ)-like alterations during adult life. SCZ is influenced by gender in age of onset, premorbid functioning, and course. Estrogen, the hormone potentially driving the gender differences in SCZ, is known to present neuroprotective effects such as regulate oxidative pathways and the expression of brain-derived neurotrophic factor (BDNF). Thus, the aim of this study was to verify if differences in gender and/or estrous cycle phase during adulthood would influence the development of behavioral and neurochemical alterations in animals neonatally administered ketamine. The results showed that ketamine-treated male (KT-male) and female-in-diestrus (KTF-diestrus, the low estrogen phase) presented significant deficits in prepulse inhibition of the startle reflex and spatial working memory, two behavioral SCZ endophenotypes. On the contrary, female ketamine-treated rats during proestrus (KTF-proestrus, the high estradiol phase) had no behavioral alterations. This correlated with an oxidative imbalance in the hippocampus (HC) of both male and KTF-diestrus female rats, that is, decreased levels of GSH and increased levels of lipid peroxidation and nitrite. Similarly, BDNF was decreased in the KTF-diestrus rats while no alterations were observed in KTF-proestrus and male animals. The changes in the HC were in contrast to those in the prefrontal cortex in which only increased levels of nitrite in all groups studied were observed. Thus, there is a gender difference in the adult rat HC in response to ketamine neonatal administration, which is based on the estrous cycle. This is discussed in relation to neuropsychiatric conditions and in particular SCZ.
Descrição: BORELLA, Vládia Célia Moreira et al. Gender and strous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine. Developmental Neurobiology, v. 76, n. 5, p. 519-532, may. 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/19479
ISSN: 1932-8451
1932-846X
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