Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19487
Título: Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine : emphasis on the neurotrophic hypothesis of depression
Autor(es): Sousa, Caren Nádia Soares de
Meneses, Lucas Nascimento
Vasconcelos, Germana Silva
Silva, Márcia Calheiros Chaves
Silva, Jéssica Calheiros da
Macêdo, Danielle
Lucena, David Freitas de
Vasconcelos, Silvânia Maria Mendes
Palavras-chave: Depressão
Antidepressivos
Antidepressants
Data do documento: Dez-2015
Editor: Psychiatry Research
Citação: SOUSA, C. N. S. ; MENESES, L. N. ; VASCONCELOS, G. S. ; SILVA, M. C. C. ; SILVA, J. C. ; MACÊDO, D. ; LUCENA, D. F. ; VASCONCELOS, S. M. M. (2015)
Abstract: Brain derived neurotrophic factor (BDNF) is linked to the pathophysiology of depression. We hypothesized that BDNF is one of the neurobiological pathways related to the augmentation effect of alpha-lipoic acid (ALA) when associated with antidepressants. Female mice were administered vehicle or CORT 20 mg/kg during 14 days. From the 15th to 21st days the animals were divided in groups that were further administered: vehicle, desvenlafaxine (DVS) 10 or 20 mg/kg, ALA 100 or 200 mg/kg or the combinations of DVS10+ALA100, DVS20+ALA100, DVS10+ALA200 or DVS20+ALA200. ALA or DVS alone or in combination reversed CORT-induced increase in immobility time in the forced swimming test and decrease in sucrose preference, presenting, thus, an antidepressant-like effect. DVS10 alone reversed CORT-induced decrease in BDNF in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). The same was observed in the HC and ST of ALA200 treated animals. The combination of DVS and ALA200 reversed CORT-induced alterations in BDNF and even, in some cases, increased the levels of this neurotrophin when compared to vehicle-treated animals in HC and ST. Taken together, these results suggest that the combination of the DVS+ALA may be valuable for treating conditions in which BDNF levels are decreased, such as depression.
Descrição: SOUSA, Caren Nádia Soares de et al. Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine : emphasis on the neurotrophic hypothesis of depression. Psychiatry Research, v. 230, n. 2, p. 211-210, dec. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/19487
ISSN: 0165-1781
1872-7123
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