Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/21481
Título: Nitric oxide and hydrogen sulfide interact when modulating gastric physiological functions in rodents
Autor(es): Lucetti, Larisse Tavares
Silva, Renan Oliveira
Santana, Ana Paula Macedo
Tavares, Bruno de Melo
Vale, Mariana Lima
Soares, Pedro Marcos Gomes
Lima Júnior, Francisco José Batista de
Magalhães, Pedro Jorge Caldas
Cunha, Fernando de Queiroz
Ribeiro, Ronaldo de Albuquerque
Medeiros, Jand-Venes Rolim
Souza, Marcellus Henrique Loiola Ponte
Palavras-chave: Óxido Nítrico
Nitric Oxide
Sulfeto de Hidrogênio
Hydrogen Sulfide
Data do documento: Jan-2017
Editor: Digestive Diseases and Sciences
Citação: LUCETTI, L. T. ; SILVA, R. O. ; SANTANA, A. P. M. ; TAVARES, B. M. ; VALE, M. L. ; SOARES, P. M. G. ; LIMA JÚNIOR, F. J. B. ; MAGALHÃES, P. J. C. ; CUNHA, F. Q. ; RIBEIRO, R. A. ; MEDEIROS, J.-V. R. ; SOUZA, M. H. L. P. (2017)
Abstract: Aim The objective was to evaluate the effects of nitric oxide (NO) and hydrogen sulfide (H2S) donors and possible interactions between these two systems in modulating gastric function. Methods Mice received saline, sodium nitroprusside (SNP), or sodium hydrosulfite (NaHS), and after 1 h, the animals were killed for immunofluorescence analysis of CSE or eNOS expressions, respectively. Other groups received saline, SNP, NaHS, Lawesson’s reagent (H2S donor), PAG + SNP, l-NAME, l-NAME + NaHS, or l-NAME + Lawesson’s reagent. Then, the gastric secretions (mucous and acid), gastric blood flow, gastric defense against ethanol, and gastric motility (gastric emptying and gastric contractility) were evaluated. Results SNP and NaHS increased the expression of CSE or eNOS, respectively. SNP or Lawesson’s reagent did not alter gastric acid secretion but increased mucus production, and these effects reverted with PAG and l-NAME treatment, respectively. SNP or NaHS increased gastric blood flow and protected the gastric mucosa against ethanol injury, and these effects reverted with PAG and l-NAME treatments, respectively. SNP delayed gastric emptying when compared with saline, and PAG partially reversed this effect. NaHS accelerate gastric emptying, and l-NAME partially reversed this effect. SNP and NaHS alone induced gastric fundus and pylorus relaxation. However, pretreatment with PAG or l-NAME reversed these relaxant effects only in the pylorus but not in the gastric fundus. Conclusion NO and H2S interact in gastric physiological functions, and this “cross-talk” is important in the control of mucus secretion, gastric blood flow, gastric mucosal defense, and gastric motility, but not in the control of basal gastric acid secretion.
Descrição: LUCETTI, Larisse Tavares et al. Nitric oxide and hydrogen sulfide interact when modulating gastric physiological functions in rodents. Digestive Diseases and Sciences, New York, v. 62, p. 93-104, jan. 2017.
URI: http://www.repositorio.ufc.br/handle/riufc/21481
ISSN: 0163-2116
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