Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/22204
Título: Sulfated polysaccharide from the marine algae Hypnea musciformis inhibits TNBS-induced intestinal damage in rats
Autor(es): Brito, Tarcisio V.
Barros, Francisco C. N.
Silva, Renan O.
Dias Júnior, Genilson J.
Cruz. Júnior, José Simião
Franco, Álvaro X.
Soares, Pedro M. G.
Abreu, Clara M. W. S.
Chaves, Luciano S.
Souza, Marcellus H. L. P.
Freitas, Ana Lúcia P.
Barbosa, André Luiz R.
Paula, Regina C. M. de
Palavras-chave: Colite
Inflamação
Data do documento: Out-2016
Editor: Carbohydrate Polymers
Citação: BRITO, T. V. ; BARROS, F. C. N. ; SILVA, R. O. ; DIAS JUNIOR, G. J. ; CRUZ JUNIOR, J. S. ; FRANCO, A. X. ; SOARES, P. M. G. ; ABREU, C. M. W. S. ; PAULA, R. C. M. ; SOUZA, M. H. L. P. ; FREITAS, A. L. P. ; BARBOSA, A.L.R . (2016)
Abstract: Sulfated polysaccharides extracted from seaweed have important pharmacological properties. Thus, the aim of this study was to characterize the sulfated polysaccharide (PLS) from the algae Hypnea musciformis and evaluate its protective effect in colitis induced by trinitrobenzene sulfonic acid in rats. The sulfated polysaccharide possess a high molecular mass (1.24 × 105 g mol−1) and is composed of a κ-carrageenan, as depicted by FT-IR and NMR spectroscopic data. PLS was administered orally (10, 30, and 60 mg/kg, p.o.) for three days, starting before TNBS (trinitrobenzene sulfonic acid) instillation (day 1). The rats were killed on day three, the portion of distal colon (5 cm) was excised and evaluated macroscopic scores and wet weight. Then, samples of the intestinal were used for histological evaluation and quantification of glutathione, malonyldialdehyde acid, myeloperoxidase, nitrate/nitrite and cytokines. Our results demonstrate that PLS reduced the colitis and all analyzed biochemical parameters. Thus, we concluded that the PLS extracted from the marine algae H. musciformis reduced the colitis in animal model and may have an important promising application in the inflammatory bowel diseases.
Descrição: BRITO, Tarcisio V. et al. Sulfated polysaccharide from the marine algae Hypnea musciformis inhibits TNBS-induced intestinal damage in rats. Carbohydrate Polymers, v. 151, p. 957-964, oct. 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/22204
ISSN: 0144-8617
1879-1344 on line
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