Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/22207
Título: Activities, and toxic effects of proteins in the Rhinella schneideri parotoid gland secretion
Autor(es): SOUSA-FILHO, LUIS M.
FREITAS, CLEVERSON D. T.
LOBO, MARINA D. P.
MONTEIRO-MOREIRA, ANA C. O.
SILVA, RENAN O.
SANTANA, LUCAS A. B.
RIBEIRO, RONALDO A.
SOUZA, MARCELLUS H. L. P.
FERREIRA, GUSTAVO P.
PEREIRA, ANNA C. T. C.
BARBOSA, ANDRÉ L. R.
LIMA, MAURO S. C. S.
OLIVEIRA, JEFFERSON S.
Palavras-chave: Anfíbios
Proteínas
Data do documento: Ago-2016
Editor: Journal of Experimental Zoology Part A-Ecological Genetics and Physiology
Citação: SOUSA-FILHO, L. M. ; FREITAS, C. D. T. ; LOBO, M. D. P. ; MONTEIRO-MOREIRA, A. C. O. ; SILVA, R. O. ; SANTANA, L. A. B. ; RIBEIRO, R. A. ; SOUZA, M. H. L. P. ; FERREIRA, G. P. ; PEREIRA, A. C. T. C. ; BARBOSA, A. L. R. ; LIMA, M. S. C. S. ; OLIVEIRA, J. S. (2016)
Abstract: Parotoid glands of amphibians are known for the production of several biologically active com- pounds having pharmacological and toxic effects in mammals. In the present work, a protein fraction obtained from Rhinella schneideri parotoid gland (RsPP) was characterized to study its biological and toxic effects. Rhinella schneideri parotoid secretion is composed of up to 30% (w/w) of soluble proteins. Tandem mass spectrometric analysis of the RsPP identied 104 proteins, in- cluding actin, beta-actin, ribosomal proteins, catalase, galectin, and uncharacterized proteins; however, no peptidases were found, and this result was reinforced by the absence of proteolytic activity. In addition, RsPP did not exhibit pro-coagulant or antibacterial effects. However, pre- treatment of mice with different doses of RsPP intraperitoneally inhibited carrageenan-induced paw edema and increased tissue myeloperoxidase activity. RsPP also reduced interleukin 1βlev- els in the peritoneal cavities and cell migration in the peritoneal cavities of an animal model of carrageenan-induced peritonitis. Subchronic treatment of animals with RsPP for 7 consecutive days did not alter the serum biochemical, renal, or liver parameters. However, a signicant re- duction in blood leukocyte count was observed. Our results showed that R. schneideri parotoid secretion contains proteins with anti-inammatory and slight toxic effects.
Descrição: SOUSA-FILHO, Luis M. et al. Biochemical profile, biological activities, and toxic effects of proteins in the Rhinella schneideri parotoid gland secretion. Journal of Experimental Zoology Part A-Ecological Genetics and Physiology, v. 325, n. 8, p. 1-14, aug. 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/22207
ISSN: 1932-5223
1932-5231 On line
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