Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/22374
Título: Structural characteristics are crucial to the benefits of guar gum in experimental osteoarthritis
Autor(es): Castro, Rondinelle R.
Silva, Christine Maria M.
Nunes, Rodolfo M.
Cunha, Pablyana L. R.
Paula, Regina Celia M. de
Feitosa, Judith P. A.
Girão, Virgínia C. C.
Pompeu, Margarida M. L.
Leite, José Alberto D.
Rocha, Francisco A.C.
Palavras-chave: Osteoartrite
Dor
Osteoarthritis
Data do documento: Out-2016
Editor: Carbohydrate Polymers
Citação: CASTRO, R.R. ; SILVA, C. M. M. ; NUNES, R. M. ; CUNHA, P. L. R. ; PAULA, R. C. M. ; FEITOSA, J. P. A. ; GIRÃO, V. C. C. ; POMPEU, M. M. L. ; LEITE, J. A. D. ; ROCHA, F. A. C (2016)
Abstract: Protein-free guar gum (DGG) was oxidized (DGGOX) or sulfated (DGGSU) by insertion of new groups in C-6 (manose) and C-6 (galactose), for DGGOX and DGGSU, respectively. Rats were subjected to anterior cruciate ligament transection (ACLT) of the knee, joint pain recorded using the articular incapacitation test, and the analgesic effect of intraarticular 100 μg DGG, DGGOX or DGGSU solutions at days 4–7 was evaluated. Other groups received DGG or saline weekly, from days 7 to 70 and joint damage assessed using histology and biochemistry as the chondroitin sulfate (CS) content of cartilage. The molar mass of CS samples was obtained by comparing their relative electrophoretic mobility to standard CS. DGG but not DGGOX or DGGSU significantly inhibited joint pain. DGG significantly reversed the increase in CS, its reduced electrophoretic mobility, and histological changes following ACLT, as compared to vehicle. Structural integrity accounts for DGG benefits in experimental osteoarthritis.
Descrição: CASTRO, Rondinelle R. et al. Structural characteristics are crucial to the benefits of guar gum in experimental osteoarthritis. Carbohydrate Polymers, v. 150, p. 392-399, oct. 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/22374
ISSN: 0144-8617 Print
1879-1344 On line
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