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dc.contributor.authorCustódio, Charllyany Sabino-
dc.contributor.authorMello, Bruna Stefânia Ferreira-
dc.contributor.authorChaves Filho, Adriano José Maia-
dc.contributor.authorLima, Camila Nayane de Carvalho-
dc.contributor.authorCordeiro, Rafaela Carneiro-
dc.contributor.authorMiyajima, Fábio Miyajima-
dc.contributor.authorVasconcelos, Silvânia Maria Mendes-
dc.contributor.authorBarichello, Tatiana-
dc.contributor.authorQuevedo, João-
dc.contributor.authorOliveira, Antônio Carlos de-
dc.contributor.authorLucena, David Freitas de-
dc.contributor.authorRéus, Gislaine Z.-
dc.contributor.authorMacedo, Danielle S.-
dc.identifier.citationCUSTÓDIO, C. S. et al. Neonatal immune challenge with lipopolysaccharide triggers long-lasting sex- and age-related behavioral and immune/neurotrophic alterations in mice : relevance to autism spectrum disorders. Molecular Neurobiology, p. 1-14, 2017.pt_BR
dc.identifier.issn0893-7648 (print version)-
dc.identifier.issn1559-1182 (electronic version)-
dc.description.abstractEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic factor—BDNF) alterations were determined in the prefrontal cortex (PFC), hippocampus (HC), and hypothalamus (HT). Since the incidence and clinical manifestations of neurodevelopmental disorders present significant sex-related differences, we sought to distinctly evaluate male and female mice. While on PN35, LPS-challenged male mice presented depressive, anxiety-like, repetitive behavior, and working memory deficits; on PN70, only depressive- and anxiety-like behaviors were observed. Conversely, females presentedpt_BR
dc.publisherMolecular Neurobiologypt_BR
dc.subjectCaracteres Sexuaispt_BR
dc.subjectSex Differencespt_BR
dc.titleNeonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- and age-related behavioral and immune/neurotrophic alterations in mice : relevance to autism spectrum disorderspt_BR
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