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dc.contributor.authorCosta, Roberta Oliveira da-
dc.contributor.authorGadelha-Filho, Carlos Vinicius Jataí-
dc.contributor.authorCosta, Ayane Edwiges Moura da-
dc.contributor.authorFeitosa, Mariana Lima-
dc.contributor.authorAraújo, Dayane Pessoa de-
dc.contributor.authorLucena, Jalles Dantas de-
dc.contributor.authorAquino, Pedro Everson Alexandre de-
dc.contributor.authorLima, Francisco Arnaldo Viana-
dc.contributor.authorNeves, Kelly Rose Tavares-
dc.contributor.authorViana, Glauce Socorro de Barros-
dc.identifier.citationCOSTA, R. O. da et al. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity, v. 2017, p. 1-10, jun. 2017.pt_BR
dc.identifier.issn1942-0994 (Online)-
dc.description.abstractParkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. Those from no-exercise groups stayed on the treadmill for the same period and, afterwards, were subjected to behavioral tests and euthanized for neurochemical and immunohistochemical assays. The data, analyzed by ANOVA and Tukey post hoc test, were considered significant for . The results showed behavioral change improvements in the 6-OHDA group, after the treadmill exercise, evaluated by apomorphine rotational behavior, open field, and rota rod tests. The exercise reduced striatal dopaminergic neuronal loss and decreased the oxidative stress. In addition, significant increases in BDNF contents and in immunoreactive cells to TH and DAT were also observed, in striata of the 6-OHDA group with exercise, relatively to those with no exercise. We conclude that exercise improves behavior and dopaminergic neurotransmission in 6-OHDA-lesioned animals. The increased oxidative stress and decreased BDNF contents were also reversed, emphasizing the importance of exercise for the PD management.pt_BR
dc.publisherOxidative Medicine and Cellular Longevitypt_BR
dc.subjectDoença de Parkinsonpt_BR
dc.subjectParkinson Diseasept_BR
dc.titleThe treadmill exercise protects against dopaminergic neuron loss and brain oxidative stress in parkinsonian ratspt_BR
dc.typeArtigo de Periódicopt_BR
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