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dc.contributor.authorSilva, Viviane Carvalho da-
dc.contributor.authorLeitão, Renata Ferreira de Carvalho-
dc.contributor.authorBrito, Gerly Anne de Castro-
dc.contributor.authorMartins, Conceição da Silva-
dc.contributor.authorFreire, Gildenio Estevam-
dc.contributor.authorAragão, Karoline Saboia-
dc.contributor.authorWanderley, Carlos Wagner de Souza-
dc.contributor.authorFreitas, Marcos Rabelo de-
dc.identifier.citationSILVA, V. C. da et al. Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil. Acta Cirurgica Brasileira, São Paulo, v. 32, n. 9, p. 712-725, sept. 2017.pt_BR
dc.identifier.issnPrint 0102-8650-
dc.identifier.issnOn-line 1678-2674-
dc.description.abstractPurpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administered 1 h prior to 5-FU and daily, until the fourth (MK886) or tenth day, when the animals were euthanized and their jugal mucosa was collected for macroscopic, histopathological, and immunohistochemical evaluation. Results: Neither montelukast nor MK-886 prevented the oral mucositis induced by 5-FU, as observed by histopathological evaluation. In addition, we did not find significant differences in the expression of inducible nitric oxide synthase-2, cyclooxygenase-2, or interleukin (IL)-1β between the experimental and control groups. However, we did observe a significant decrease in tumor necrosis factor (TNF)-α expression for all doses of montelukast; we also observed a significant decrease in IL-10 with 40 mg/kg/d and MK 886. Conclusions: Cysteinyl leukotrienes do not play an important role in experimental oral mucositis induced by 5-FU. There is a modulating action specifically on TNF-α.pt_BR
dc.publisherActa Cirurgica Brasileirapt_BR
dc.subjectAraquidonato 5-Lipoxigenasept_BR
dc.titleRole of the route of leukotrienes in an experimental model of oral mucositis induced by 5- fluorouracil 1pt_BR
dc.typeArtigo de Periódicopt_BR
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