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dc.contributor.authorPortes, Silvana Augusta Rodrigues-
dc.contributor.authorCarvalho-Costa, Filipe Anibal-
dc.contributor.authorRocha, Monica Simões-
dc.contributor.authorFumian, Tulio Machado-
dc.contributor.authorMaranhão, Adriana Gonçalves-
dc.contributor.authorAssis, Rosane Maria de-
dc.contributor.authorXavier, Maria da Penha Trindade Pinheiro-
dc.contributor.authorRocha, Myrna Santos-
dc.contributor.authorMiagostovich, Marize Pereira-
dc.contributor.authorLeite, José Paulo Gagliardi-
dc.contributor.authorVolotão, Eduardo de Mello-
dc.identifier.citationPORTES, S. A. R. et al. Enteric viruses in HIV-1 seropositive and HIV-1 seronegative children with diarrheal diseases in Brazil. Enteric viruses in HIV-1 seropositive and HIV-1 seronegative children with diarrheal diseases in Brazil. PLoS One, v. 12, n. 8, p. 1-15, aug. 2017.pt_BR
dc.description.abstractDiarrheal diseases (DD) have distinct etiological profiles in immune-deficient and immune-competent patients. This study compares detection rates, genotype distribution and viral loads of different enteric viral agents in HIV-1 seropositive (n = 200) and HIV-1 seronegative (n = 125) children hospitalized with DD in Rio de Janeiro, Brazil. Except for group A rotavirus (RVA), which were detected through enzyme immunoassay, the other enteric viruses (norovirus [NoV], astrovirus [HAstV], adenovirus [HAdV] and bocavirus [HBoV]) were detected through PCR or RT-PCR. A quantitative PCR was performed for RVA, NoV, HAstV, HAdV and HBoV. Infections with NoV (19% vs. 9.6%; p<0.001), HBoV (14% vs. 7.2%; p = 0.042) and HAdV (30.5% vs. 14.4%; p<0.001) were significantly more frequent among HIV-1 seropositive children. RVA was significantly less frequent among HIV-1 seropositive patients (6.5% vs. 20%; p<0.001). Similarly, frequency of infection with HAstV was lower among HIV-1 seropositive children (5.5% vs. 12.8%; p = 0.018). Among HIV-1 seropositive children 33 (16.5%) had co-infections, including three enteric viruses, such as NoV, HBoV and HAdV (n = 2) and NoV, HAstV and HAdV (n = 2). The frequency of infection with more than one virus was 17 (13.6%) in the HIV-1 negative group, triple infection (NoV + HAstV + HBoV) being observed in only one patient. The median viral load of HAstV in feces was significantly higher among HIV-1 positive children compared to HIV-1 negative children. Concerning children infected with RVA, NoV, HBoV and HAdV, no statistically significant differences were observed in the medians of viral loads in feces, comparing HIV-1 seropositive and HIV-1 seronegative children. Similar detection rates were observed for RVA, HAstV and HAdV, whilst NoV and HBoV were significantly more prevalent among children with CD4+ T lymphocyte count below 200 cells/mm3. Enteric viruses should be considered an important cause of DD in HIV-1 seropositive children, along with pathogens more classically associated with intestinal infections in immunocompromised hosts.pt_BR
dc.publisherPLoS Onept_BR
dc.titleEnteric viruses in HIV-1 seropositive and HIV-1 seronegative children with diarrheal diseases in Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
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