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dc.contributor.authorOliveira, Valzimeire do Nascimento de-
dc.contributor.authorLima-Neto, Abelardo Barbosa Moreira-
dc.contributor.authorTilburg, Maurício Fraga van-
dc.contributor.authorMonteiro-Moreira, Ana Cristina de Oliveira-
dc.contributor.authorLobo, Marina Duarte Pinto-
dc.contributor.authorRondina, Davide-
dc.contributor.authorFernandes, Virgínia Oliveira-
dc.contributor.authorMontenegro, Ana Paula Dias Rangel-
dc.contributor.authorMontenegro Júnior, Renan Magalhães-
dc.contributor.authorGuedes, Maria Izabel Florindo-
dc.identifier.citationOLIVEIRA, Valzimeire do Nascimento de et al. Proteomic analysis to identify candidate biomarkers associated with type 1 diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 11, p. 289–301, jun. 2018.pt_BR
dc.description.abstractPurpose: Type 1 diabetes mellitus (DM1) is one of the most common chronic diseases observed during childhood. The incidence of DM1 is increasing worldwide, and there is currently no way to prevent or delay the onset or to cure the disease. Most diseases, including diabetes, stem from abnormalities in the functioning of proteins, and some studies have reported the expression of protein variation to be involved in the development of DM1. Thus, the aim of this study was to investigate the differential expression of serum proteins in patients with DM1. Materials and methods: Serum of patients with DM1 (n=30) and healthy controls (n=30) was collected. A proteomic approach was used with depletion of albumin and immunoglobulin G chromatography on serum samples followed by data-independent, label-free mass spectrometric analysis. Results: A total of eight serum proteins were identified as being differentially expressed and involved in the immune system, lipid metabolism, and pathways of coagulation. DM1 was associated with the upregulation of six proteins: alpha-2-macroglobulin, apolipoprotein A-II, β2 glycoprotein I, Ig alpha-2 chain C region, alpha-1-microglobulin, and prothrombin. A total of two proteins were downregulated, including pregnancy zone protein and complement C4. Conclusion: To the best of our knowledge, these findings show differential expression of proteins revealing new proteins that may be involved in the development and progression of diabetes.pt_BR
dc.publisherDiabetes, Metabolic Syndrome and Obesity: Targets and Therapypt_BR
dc.subjectMass Spectrometrypt_BR
dc.subjectEspectrometria de Massaspt_BR
dc.titleProteomic analysis to identify candidate biomarkers associated with type 1 diabetespt_BR
dc.typeArtigo de Periódicopt_BR
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