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|Title in Portuguese:||Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunífera against Triton WR-1339 and hyperlipidemic diet in mice|
|Author:||A. Filho, A. C. V.|
Rodrigues, P. A. S.
Benjamin, S. R.
Paim, R. T. T.
Holanda, M. O.
Silva, J. Y. G.
Milo, T. S.
Vieira, I. G. P.
Queiroz, M. G. R.
Guedes, M. I. F.
|Publisher:||Environmental Toxicology and Pharmacology|
|Citation:||A. FILHO, A. C. V. et al. Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunífera against Triton WR-1339 and hyperlipidemic diet in mice. nvironmental Toxicology and Pharmacology, Amsterdam, v. 56, p. 198-203, dec. 2017.|
|Abstract:||Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and triglycerides were significantly reduced plasma levels in PCO-C at the dose of 100 mg/kg in a model of acute and chronic dyslipidemia. Histological studies showed that PCO-C has no hepatotoxic effect and reduces hepatic steatosis in animals that consumed hyperlipidemic ration. Thus, it was concluded that PCO-C isolated from Copernicia Prunifera was effective in reducing total cholesterol and triglyceride levels in both dyslipidemia induction models. The finding indicates that PCO-C might be beneficial in treatment of hyperlipidemia and atherosclerosis.|
|Appears in Collections:||DFAR - Artigos publicados em revistas científicas|
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