Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/4935
Título: The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
Autor(es): Bezerra, Cristianne Sousa
Vilar, Maria do Livramento Leitão
Frutuoso, M.S.
Lima, D.M.
Pompeu, Margarida Maria de Lima
Palavras-chave: Imunomodulação
Sistema Imunológico
Data do documento: Abr-2011
Editor: Brazilian Journal of Medical and Biological Research
Citação: BEZERRA, C. S. ; VILAR, M. L. L. ; FRUTUOSO, M. S. ; LIMA, D. M. ; POMPEU, M. M. L. (2011)
Abstract: The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAMSAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAMSAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.
Descrição: BEZERRA, Cristianne Sousa ; VILAR, Maria do Livramento Leitão ; FRUTUOSO, M.S. ; ARRUDA, S.M. ; LIMA, D.M. ; POMPEU, Margarida Maria de Lima. The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 44, n. 4, p. 276-282, abr. 2011.
URI: http://www.repositorio.ufc.br/handle/riufc/4935
Aparece nas coleções:DMC - Artigos publicados em revistas científicas

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
2011_art_csbezerra.pdf652,29 kBAdobe PDFVisualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.