Use este identificador para citar ou linkar para este item:
|Título:||Comparative Dynamics, Morbidity and Mortality Burden of Pediatric Viral Respiratory Infections in an Equatorial City|
|Autor(es):||Alonso, Wladimir J.|
Laranjeira, Bruno J.
Pereira, Samuel A.R.
Florencio, Caroline M.G.D.
Moreno, Eduardo C.
Miller, Mark A.
Moura, Fernanda E.A.
|Data do documento:||Jan-2012|
|Editor:||The Pediatric Infectious Disease Journal|
|Citação:||ALONSO, W. J. ; LARANJEIRA, B.J. ; PEREIRA, S. A.R. ; FLORÊNCIO, C. M.G.D. ; MORENO, E. C. ; MILLER, M. A. ; GIGLIO, R. ; SCHUCK- PAIM, C. ; MOURA, F. E.A. (2012)|
|Abstract:||Background—Although acute respiratory infections (ARIs) are the global leading cause of pediatric morbidity and mortality, the relative impact of viral pathogens on pediatric ARIs is still poorly understood, especially in equatorial settings. Long-term studies of multiple viruses concurrently circulating in these regions are still lacking. Here we report the results of a systematic prospective surveillance of multiple respiratory viruses conducted every weekday for nearly a decade in an equatorial city in Brazil. Methods—We analyze the relative burden of influenza, parainfluenza, respiratory syncytial virus (RSV), adenovirus and metapneumovirus, their seasonality and their association with climatic and demographic factors, ARI diagnosis and pediatric mortality. Results and Conclusions—RSV was the primary driver of severe childhood respiratory infections, including pneumonia. RSV was also the virus most strongly associated with respiratory-associated deaths, with RSV circulation and pediatric mortality being in phase. Influenza was the second most common cause of childhood ARIs but, similarly to parainfluenza, adenovirus and metapneumovirus, it was mostly associated to upper tract infections, and peaked much earlier than mortality. The results also show that viral circulation can be strongly seasonal even in equatorial regions, which lack seasons with low temperatures: while parainfluenza predominantly circulated in the dry season, RSV and influenza were concentrated in the rainy season. The consistent epidemiological patterns observed can be used for an effective adjustment of the timing of therapeutic and prophylactic interventions in this and potentially other equatorial regions.|
|Descrição:||ALONSO, Wladimir J. ; LARANJEIRA, Bruno J. ; PEREIRA, Samuel A.R. ; FLORÊNCIO, Caroline M.G.D. ; MORENO, Eduardo C. ; MILLER, Mark A. ; GIGLIO, Ricardo ; SCHUCK-PAIM, Cynthia ; MOURA, Fernanda E.A. Comparative Dynamics, Morbidity and Mortality Burden of Pediatric Viral Respiratory Infections in an Equatorial City. The Pediatric Infectious Disease Journal, Rockville Pike, Bethesda, v. 31, n. 1, p. 9-14, jan. 2012.|
|Aparece nas coleções:||DMC - Artigos publicados em revistas científicas|
Arquivos associados a este item:
|2012_art_bjlaranjeira.pdf||2,38 MB||Adobe PDF||Visualizar/Abrir|