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|Title in Portuguese:||Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae)|
|Author:||Ferraz, Rosana P.C. Ferraz|
Cardoso, Gabriella M.B.
Silva, Thanany B. da
Fontes, José Eraldo do N.
Prata, Ana Paula do N.
Carvalho, Adriana A.
Moraes Filho, Manoel Odorico de
Costa, Emmanoel V.
Bezerra, Daniel P.
|Citation:||FERRAZ, R. P. C. et al. Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae). Food Chemistry. Londres, v. 141, n. 1, p. 196-200, nov. 2013.|
|Abstract:||The aim of this study was to investigate the chemical composition and anticancer effect of the leaf essen- tial oil of Xylopia frutescens in experimental models. The chemical composition of the essential oil was analysed by GC/FID and GC/MS. In vitro cytotoxic activity of the essential oil was determined on cultured tumour cells. In vivo antitumour activity was assessed in Sarcoma 180-bearing mice. The major com- pounds identified were ( E )-caryophyllene (31.48%), bicyclogermacrene (15.13%), germacrene D (9.66%), d -cadinene (5.44%), viridiflorene (5.09%) and a -copaene (4.35%). In vitro study of the essential oil dis- played cytotoxicity on tumour cell lines and showed IC 50 values ranging from 24.6 to 40.0 l g/ml for the NCI-H358M and PC-3M cell lines, respectively. In the in vivo antitumour study, tumour growth inhi- bition rates were 31.0–37.5%. In summary, the essential oil was dominated by sesquiterpene constituents and has some interesting anticancer activity|
|metadata.dc.type:||Artigo de Periódico|
|Appears in Collections:||DFIFA - Artigos publicados em revista científica|
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