Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/5603
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dc.contributor.authorOliveira, Francisco A.-
dc.contributor.authorCosta, Charllynton L.S.-
dc.contributor.authorChaves, Mariana H.0-
dc.contributor.authorAlmeida, Fernanda Regina de Castro-
dc.contributor.authorCavalcante, Ítalo José Mesquita-
dc.contributor.authorLima, Alana Fonteles-
dc.contributor.authorLima Jr., Roberto César Pereira-
dc.contributor.authorSilva, Regilane M.-
dc.contributor.authorCampos, Adriana Rolim-
dc.contributor.authorSantos, Flavia Almeida-
dc.contributor.authorRao, Vietla Satyanarayana N.-
dc.date.accessioned2013-08-12T12:37:39Z-
dc.date.available2013-08-12T12:37:39Z-
dc.date.issued2005-05-
dc.identifier.citationOLIVEIRA, F. A. et al. Attenuation of capsaicin-induced acute and visceral nociceptive pain by a-and h-amyrin, a triterpene mixture isolated from Protium heptaphyllum resin in mice. Life Sciences, Elmsford, NY, v. 77, n. 23, p. 2942-2952, maio, 2005.pt_BR
dc.identifier.issn0024-3205-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/5603-
dc.description.abstractThe triterpene mixture, a - and h -amyrin, isolated from Protium heptaphyllum resin was evaluated on capsaicin- evoked nociception in mice. Orally administered a - and h -amyrin (3 to 100 mg/kg) significantly suppressed the nociceptive behaviors—evoked by either subplantar (1.6 A g) or intracolonic (149 A g) application of capsaicin. The antinociception produced by a - and h -amyrin against subplantar capsaicin-induced paw-licking behavior was neither potentiated nor attenuated by ruthenium red (1.5 mg/kg, s.c.), a non-specific antagonist of vanilloid receptor (TRPV1), but was greatly abolished in animals pretreated with naloxone (2 mg/kg, s.c.), suggesting an opioid mechanism. However, participation of a 2 -adrenoceptor involvement was unlikely since yohimbine (2 mg/ kg, i.p.) pretreatment failed to block the antinociceptive effect of a - and h -amyrin in the experimental model of visceral nociception evoked by intracolonic capsaicin. The triterpene mixture (3 to 30 mg/kg, p.o.) neither altered significantly the pentobarbital sleeping time, nor impaired the ambulation or motor coordination in open-field and rota-rod tests, respectively, indicating the absence of sedative or motor abnormality that could account for its antinociception. Nevertheless, a - and h -amyrin could significantly block the capsaicin (10 mg/kg, s.c.)-inducedpt_BR
dc.language.isoenpt_BR
dc.publisherLife Sciencespt_BR
dc.subjectCapsaicinapt_BR
dc.subjectRatospt_BR
dc.titleAttenuation of capsaicin-induced acute and visceral nociceptive pain by a - and h -amyrin, a triterpene mixture isolated from Protium heptaphyllum resin in micept_BR
dc.typeArtigo de Periódicopt_BR
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