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Title in Portuguese: Atrial stretch delays gastric emptying of liquids in awake rats
Author: Palheta Jr., Raimundo Campos
Silva, Moisés Tolentino Bento da
Barbosa, H.L.G.
Pinheiro, Ana Débora Nunes
Cardoso, KKátia Virgínia Viana
Graça, José Ronaldo Vasconcelos da
Magalhães, Pedro Jorge Caldas
Oliveira, Ricardo Brandt de
Santos, Armênio Aguiar dos
Keywords: Óxido Nítrico
Issue Date: Mar-2013
Publisher: Life Sciences
Citation: PALHETA JR., R.C. et al. Atrial stretch delays gastric emptying of liquids in awake rats. Life sciences, Elmsford, NY, v. 92, n. 10, p. 569-575, mar. 2013.
Abstract: Aims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later. Key findings: Heart rate and CVP valueswere transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it. Significance: Atrial stretch inhibited the gastric emptying.
metadata.dc.type: Artigo de Periódico
ISSN: 0024-3205
Appears in Collections:DFIFA - Artigos publicados em revista científica

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