Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/5717
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dc.contributor.authorAraújo, Dayane Pessoa de-
dc.contributor.authorSousa, Caren Nádia Soares De-
dc.contributor.authorAraújo, Paulo Victor Pontes-
dc.contributor.authorMenezes, Carlos Eduardo de Souza-
dc.contributor.authorRodrigues, Francisca Taciana Sousa-
dc.contributor.authorEscudeiro, Sarah Souza-
dc.contributor.authorLima, Nicole Brito Cortez-
dc.contributor.authorPatrocínio, Manoel Claúdio Azevedo-
dc.contributor.authorAguiar, Lissiana Magna Vasconcelos de-
dc.contributor.authorViana, Glauce Socorro de Barros-
dc.contributor.authorVasconcelos, Silvânia Maria Mendes-
dc.date.accessioned2013-09-02T13:07:08Z-
dc.date.available2013-09-02T13:07:08Z-
dc.date.issued2013-
dc.identifier.citationARAÚJO, D. P. de et al. Behavioral and neurochemical effects of alpha-lipoic acid in the model of Parkinson’s disease induced by unilateral stereotaxic Iijection of 6-Ohda in rat. Evidence-Based Complementary and Alternative Medicine, v. 2013, p.1-13, jun, 2013.pt_BR
dc.identifier.issn1741-427X-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/5717-
dc.description.abstractThis study aimed to investigate behavioral and neurochemical effects of 𝛼-lipoic acid (100mg/kg or 200mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity. 𝛼-Lipoic acid decreased body rotations induced by apomorphine, as well as caused an improvement in motor performance by increasing locomotor activity in the open field test and use of contralateral paw (in the opposite side of the lesion produced by 6-OHDA) at cylinder test. 𝛼-lipoic acid showed antioxidant effects, decreasing lipid peroxidation and nitrite levels and interacting with antioxidant system by decreasing of endogenous catalase activity. Therefore, 𝛼-lipoic acid prevented the damage induced by 6-OHDA or by chronic use of L-DOPA in dopaminergic neurons, suggesting that 𝛼-lipoic could be a new therapeutic target for Parkinson’s disease prevention and treatment.pt_BR
dc.language.isoenpt_BR
dc.publisherEvidence-Based Complementary and Alternative Medicinept_BR
dc.subjectDoença de Parkinsonpt_BR
dc.subjectRatospt_BR
dc.titleBehavioral and neurochemical effects of alpha-lipoic acid in the model of Parkinson’s disease induced by unilateral stereotaxic Injection of 6-Ohda in ratpt_BR
dc.typeArtigo de Periódicopt_BR
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