Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/7208
Title in Portuguese: Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
Author: Silva, Mauro G.
Camara, Celso A.
Silva, Tania M. S.
Feitosa, Anderson C. S.
Meira, Assuero S.
Pessoa, Cláudia
Keywords: Paládio
Neoplasias
Issue Date: Aug-2013
Publisher: Journal of the Brazilian Chemical Society
Citation: SILVA, M. G. et al. Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines. Journal of the Brazilian Chemical Society, São Paulo, SP, v. 24, n. 9, p. 1420-1426, ago. 2013.
Abstract in Portuguese: Uma série de derivados 2,3-diino-1,4-naftoquinona foi sintetizada a partir do 2,3-dibromo- 1,4-naftoquinona e diversos alquinos terminais funcionalizados usando a reação de acoplamento de Sonogashira catalisada por paládio. Os compostos foram submetidos à avaliação do potencial citotóxico em três linhagens de células tumorais, OVCAR-8 (ovário), PC-3M (próstata) e NCI‑H358M (pulmão), apresentando, no geral, resultados satisfatórios para inibição do crescimento celular.
Abstract: A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung carcinoma (NCI-H358M), presenting, in general, satisfactory results for inhibition of cell growth.
URI: http://www.repositorio.ufc.br/handle/riufc/7208
metadata.dc.type: Artigo de Periódico
ISSN: 0103-5053 Impresso
1678-4790 On-line
Appears in Collections:DFIFA - Artigos publicados em revista científica

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