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Título: Disseminated histoplasmosis and AIDS : relapse and late mortality in endemic area in north-eastern Brazil
Autor(es): Damasceno, Lisandra Serra
Ramos Jr., Alberto Novaes
Alencar, Carlos Henrique Morais
Lima, Daniel Teixeira
Sidrim, José Júlio Costa
Gonçalves, Maria Vânia Freitas
Mesquita, Jacó Ricarte Lima de
Leitão, Terezinha do Menino Jesus Silva
Palavras-chave: AIDS
Data do documento: Set-2013
Editor: Mycoses
Citação: DAMASCENO, L. S. ; RAMOS JR., A. N. ALENCAR, C. H. M. ; LIMA, D. T. ; SIDRIM, J. J. C. ; GONÇALVES, M. V. F. ; MESQUITA, J. R. L. ; LEITÃO, T. M. J. S. (2014)
Abstract: The State of Cear a in north-eastern Brazil has one of the highest rates in the world of relapse and death due to disseminated histoplasmosis (DH) in acquired immunodeficiency syndrome (AIDS) patients. The objective of this study is to characterise the relapse and mortality of DH in AIDS cases residents in Cear a. We performed a retrospective analysis of the medical records of AIDS patients who had a first episode of DH from 2002 to 2008. We analysed the outcomes until December 31, 2010. A total of 145 patients participated in the study. The mean clinical follow-up duration was 3.38 years (SD = 2.2; 95% CI = 3.01–3.75). The majority of the subjects were male with a mean age of 35 years (SD = 2.2; 95% CI = 3.01–3.75) and were born in the capital of Cear a. DH was the first manifestation of AIDS in 59% of the patients. The relapse rate was 23.3%, with a disseminated presentation in 90% of these patients. The overall mortality during the study period was 30.2%. The majority of patients who relapsed or died had irregular treatment with antifungals or highly active antiretroviral therapy and did not have active clinical follow-up. High rates of recurrence and mortality were found in AIDS-associated DH in this area of the country.
Descrição: DAMASCENO, Lisandra Serra ; RAMOS JR., Alberto Novaes ; ALENCAR, Carlos Henrique Morais ; LIMA, Daniel Teixeira ; SIDRIM, José Júlio Costa ; GONÇALVES, Maria Vânia Freitas ; MESQUITA, Jacó Ricarte Lima de ; LEITÃO, Terezinha do Menino Jesus Silva. Disseminated histoplasmosis and AIDS : relapse and late mortality in endemic area in north-eastern Brazil. Mycoses, Berlin, v. 56, n. 5, p. 520-6, 2013.
ISSN: 0933-7407
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