Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/9851
Título: Gabapentin, a synthetic analogue of gamma aminobutyric acid, reverses systemic acute Inflammation and oxidative stress in mice
Autor(es): Dias, Jordana Maia
Brito, Tarcisio Vieira de
Magalhães, Diva de Aguiar
Santos, Pammela Weryka da Silva
Batista, Jalles Arruda
Dias, Eulina Gabriela do Nascimento
Fernandes, Heliana de Barros
Damasceno, Samara Rodrigues Bonfim
Silva, Renan O.
Aragão, Karoline S.
Souza, Marcellus H. L. P.
Medeiros, Jand-Venes R.
Barbosa, André Luiz R.
Palavras-chave: Estresse Oxidativo
Inflamação
Data do documento: Out-2014
Editor: Inflammation
Citação: DIAS, J. M. ; BRITO, T. V. ; MAGALHÃES, D. A. ; SANTOS, P. W. S. ; BATISTA, J. A. ; DIAS, E. G. N. ; FERNANDES, H. B. DAMASCENO, S. R. B. ; SILVA, R. O. ; ARAGÃO, K. S. ; SOUZA, M. H. L. P. ; MEDEIROS, J.-V. R. ; BARBOSA, A. L. R. (2014)
Abstract: The aim of this study was to investigate the potential anti-inflammatory and anti-oxidant effects of gabapentin (GBP) inmice. The anti-inflammatory and anti-oxidant effects were evaluated using various mediators that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, proinflammatory cytokine levels, glutathione (GSH) consumption, and malondialdehyde (MDA) production in mice. Pretreatment of mice with GBP (1 mg/kg) significantly reduced carrageenan or dextran-induced paw edema (P<0.05) when compared to vehicle group. Adding to this, GBP (1 mg/kg) significantly inhibited paw edema induced by histamine, serotonin, bradikinin, 48/80 compound, and prostaglandin E2. In the carrageenan-induced peritonitis model, GBP significantly decreased total and differential leukocyte counts and reduced the levels of MPO activity in the plantar tissue and IL-1β and TNF-α concentrations in the peritoneal exudate. The same dose of GBP also decreased the MDA concentration and increased the levels of GSH into the peritoneal fluid. In summary, our results demonstrated that GBP exhibited anti-inflammatory activity in mice by reducing the action of inflammatory mediators, neutrophil migration and proinflammatory cytokine levels, and anti-oxidant properties by decreasing the concentration of MDA and increasing the GSH content. These observations raise the possibility that GBP could be used to improve tissue resistance to damage during inflammatory conditions.
Descrição: DIAS, Jordana Maia ; BRITO, Tarcisio Vieira de ; MAGALHÃES, Diva de Aguiar ; SANTOS, Pammela Weryka da Silva ; BATISTA, Jalles Arruda ; DIAS, Eulina Gabriela do Nascimento ; FERNANDES, Heliana de Barros ; DAMASCENO, Samara Rodrigues Bonfim ; SILVA, Renan O. ; ARAGÃO, Karoline S. ; SOUZA, Marcellus H. L. P. ; MEDEIROS, Jand-Venes R. ; BARBOSA, André Luiz R. Gabapentin, a synthetic analogue of gamma aminobutyric acid, reverses systemic acute inflammation and oxidative stress in mice. Inflammation, v. 37, p. 1826-1836, out. 2014.
URI: http://www.repositorio.ufc.br/handle/riufc/9851
ISSN: 0360-3997 (Print)
1573-2576 (Online)
Aparece nas coleções:DFIFA - Artigos publicados em revista científica

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