Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/9852
Título: Sulfated-polysaccharide fraction extracted from red algae Gracilaria birdiae ameliorates trinitrobenzenesulfonic acid-induced colitis in rats
Autor(es): Brito, Tarcisio V.
P. Neto, José P. R.
Prudêncio, Rafael S.
Batista, Jalles A.
C. Júnior, José S.
Silva, Renan O.
Franco, Álvaro X.
Aragão, Karoline Saboia
Soares, Pedro Marcos Gomes
Souza, Marcellus Henrique Loiola Ponte
Chaves, Luciano S.
Freitas, Ana Lúcia Ponte
Medeiros, Jand-V. Rolim
Barbosa, André L. R.
Palavras-chave: Antioxidantes
Colite
Rodófitas
Data do documento: Ago-2014
Editor: Journal of Pharmacy and Pharmacology
Citação: BRITO, T. V. ; P. NETO, J. P. R. ; PRUDÊNCIO, R. S. ; BATISTA, J. A. ; C. JÚNIOR, J. S. ; SILVA, R. O. ; FRANCO, Á. X. ; ARAGÃO, K. S. ; SOARES, P. M. G. ; SOUZA, M. H. L. P. ; CHAVES, L. S. ; FREITAS, A. L. P. ; MEDEIROS, J.-V. R. ; BARBOSA, A. L. R. (2014)
Abstract: Objectives The aim of this study was to evaluate the protective effect of the sulfated-polysaccharide (PLS) fraction extracted from the seaweed Gracilaria birdiae in rats with trinitrobenzenesulfonic acid (TNBS)-induced colitis. Methods In the experiments involving TNBS-induced colitis, rats were pretreated with polysaccharide extracted from G. birdiae (PLS: 30, 60 and 90 mg/kg, 500 μL p.o.) or dexamethasone (control group: 1 mg/kg) once daily for 3 days starting before TNBS instillation (day 1). The rats were killed on the third day, the portion of distal colon was excised and washed with 0.9% saline and pinned onto a wax block for the evaluation of macroscopic scores. Samples of the intestinal tissue were used for histological evaluation and assays for glutathione (GSH) levels, malonyldialdehyde (MDA) concentration, myeloperoxidase (MPO) activity, nitrate and nitrite (NO3/NO2) concentration and cytokines levels. Key findings PLS treatment reduced the macroscopic and microscopic TNBSinduced intestinal damage. Additionally, it avoided the consumption of GSH, decreased pro-inflammatory cytokine levels, MDA and NO3/NO2 concentrations and diminished the MPO activity. Conclusions Our results suggest that the PLS fraction has a protective effect against intestinal damage through mechanisms that involve the inhibition of inflammatory cell infiltration, cytokine releasing and lipid peroxidation.
Descrição: BRITO, Tarcisio V. ; P. NETO, José P. R. ; PRUDÊNCIO, Rafael S. ; BATISTA, Jalles A. C. JÚNIOR, José S. ; SILVA, Renan O. ; FRANCO, Álvaro X. ; ARAGÃO, Karoline S. ; SOARES, Pedro M. G. ; SOUZA, Marcellus H. L. P. ; CHAVES, Luciano S. ; FREITAS, Ana L. P. ; MEDEIROS, Jand-V. R. ; BARBOSA, André L. R. Sulfated-polysaccharide fraction extracted from red algae Gracilaria birdiae ameliorates trinitrobenzenesulfonic acid-induced colitis in rats. Journal of Pharmacy and Pharmacology, v. 66, n. 8, p. 1161-70, ago. 2014.
URI: http://www.repositorio.ufc.br/handle/riufc/9852
ISSN: 2042-7158 Online
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