Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/10294
Título: Topical antinociceptive effect of vanillosmopsis arborea baker on acute corneal pain in mice
Autor(es): Leite, Laura Hévila Inocêncio
Leite, Gerlânia de Oliveira
Coutinho, Thales Silva
Sousa, Severino Denício Gonçalves de
Sampaio, Renata Souza
Costa, José GalbertoMartins da
Menezes, Irwin Rose Alencar de
Campos, Adriana Rolim
Palavras-chave: Dor Aguda
Medição da Dor
Data do documento: 2014
Editor: Evidence-Based Complementary and Alternative Medicine
Citação: LEITE, L. H. I. ; LEITE, G. O. ; COUTINHO, T. S. ; SOUSA, S. D. G. ; SAMPAIO, R. S. ; COSTA, J. G. M. ; MENEZES, I. R. A. ; CAMPOS, A. R. (2014)
Abstract: This study aimed to assess the possible topical antinociceptive activity of Vanillosmopsis arborea Baker essential oil (EOVA) and to clarify the underlying mechanism, using the acute model of chemical (eye wiping) nociception in mice. EOVA (25 to 200mg/kg; p.o. and topical) evidenced significant antinociception against chemogenic pain in the test model of formalin-induced neuroinflammatory pain. Local application of 5MNaCl solution on the corneal surface of the eye produced a significant nociceptive behavior, characterized by eyewiping.Thenumber of eyewipes was counted during the first 30 s. EOVA(25, 50, 100, and 200mg/kg; p.o. and topical) significantly decreased the number of eye wipes. Naloxone, yohimbine, L-NAME, theophylline, glibenclamide, and ruthenium red had no effect on the antinociceptive effect of EOVA. However, ondansetron, p-chlorophenylalanine methyl ester (PCPA), capsazepine, prazosin, and atropine prevented the antinociception induced by EOVA. These results indicate the topical antinociceptive effect of EOVA and showed that 5-HT, 𝛼1, TRPV1, and central muscarinic receptors might be involved in the antinociceptive effect of EOVA in the acute corneal model of pain in mice.
Descrição: LEITE, Laura Hévila Inocêncio ; LEITE, Gerlânia de Oliveira ; COUTINHO, Thales Silva ; SOUSA, Severino Denício Gonçalves de ; SAMPAIO, Renata Souza ; COSTA, José Galberto Martins da ; MENEZES, Irwin Rose Alencar de ; CAMPOS, Adriana Rolim. Topical antinociceptive effect of vanillosmopsis arborea baker on acute corneal pain in mice. Evidence-Based Complementary and Alternative Medicine, v. 2014, p. 1-6, 2014.
URI: http://www.repositorio.ufc.br/handle/riufc/10294
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