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Title in Portuguese: Synthesis and antimicrobial activities of 5-arylidene-thiazolidine-2,4-dione derivatives
Author: Silva, Ivanildo Mangueira da
Silva Filho, João da
Santiago, Priscila Brandão Gomes da Silva
Egito, Micalyne Soares do
Souza, Carlos André de
Gouveia, Frederico Leite
Ximenes, Rafael Matos
Sena, Kêsia Xisto da Fonseca Ribeiro de
Faria, Antonio Rodolfo de
Brondani, Dalci José
Albuquerque, Julianna Ferreira Cavalcanti de
Keywords: Resistência a Medicamentos
Issue Date: May-2014
Publisher: BioMed Research International
Citation: SILVA, I. M. et al. Synthesis and antimicrobial activities of 5-arylidene-thiazolidine-2,4-dione derivatives. BioMed Research International, v. 2014, p. 1-9, maio, 2014.
Abstract: Antibiotic resistance is considered one of the world’s major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gramnegative, and alcohol acid resistant bacteria and yeast.The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 𝜇g/mL.
metadata.dc.type: Artigo de Periódico
Appears in Collections:DFIFA - Artigos publicados em revista científica

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