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Title in Portuguese: Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, cathepsin K and Up- regulates OPG in an experimental periodontitis model
Author: Araújo, Aurigena Antunes de
Varela, Hugo
Brito, Gerly Anne de Castro
Medeiros, Caroline Addison Carvalho Xavier de
Araújo, Lorena de Souza
Nascimento, José Heriberto Oliveira do
Araújo Júnior, Raimundo Fernandes de
Keywords: Catepsina K
Issue Date: May-2014
Publisher: Plos One
Citation: ARAÚJO, A. A. de et al. Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, cathepsin K and up-regulates OPG in an experimental periodontitis model. Plos One, v. 9, n. 5, p. e96750, maio, 2014.
Abstract: Aims: The aim of this study was to evaluate the effects of azilsartan (AZT) on bone loss, inflammation, and the expression of matrix metallo proteinases (MMPs), receptor activator of nuclear factor kB ligand (RANKL), receptor activator of nuclear factor kB (RANK), osteoprotegerin (OPG), cyclooxygenase-2 (COX-2), and cathepsin K in periodontal tissue in a rat model of ligature-induced periodontitis. Materials and Methods: Male Wistar albino rats were randomly divided into 5 groups of 10 rats each: (1) nonligated, water; (2) ligated, water; (3) ligated, 1 mg/kg AZT; (4) ligated, 5 mg/kg AZT; and (5) ligated, 10 mg/kg AZT. All groups were treated with saline or AZT for 10 days. Periodontal tissues were analyzed by histopathology and immunohistochemical detection of MMP-2, MMP-9, COX-2, RANKL, RANK, OPG, and cathepsin K. Levels of IL-1b, IL-10, TNF-a, myeloperoxidase (MPO), and glutathione (GSH) were determined by ELISA. Results: Treatment with 5 mg/kg AZT resulted in reduced MPO (p,0.05) and IL-1b (p,0.05), increased levels of IL-10 (p, 0.05), and reduced expression of MMP-2, MMP-9, COX-2, RANK, RANKL, cathepsin K, and increased expression of OPG. Conclusions: These findings reveal that AZT increases anti-inflammatory cytokines and GSH and decreases bone loss in ligature-induced periodontitis in rats.
metadata.dc.type: Artigo de Periódico
Appears in Collections:DFIFA - Artigos publicados em revista científica

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