Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/11039
Title in Portuguese: Effects of chronic administration of tamsulosin and tadalafil, alone or in combination, in rats with bladder outlet obstruction induced by chronic nitric oxide deficiency
Author: Regadas, Rommel Prata
Reges, Ricardo
Cerqueira, João Batista Gadelha
Sucupira, Daniel Gabrielle
Jamacaru, Francisco Vagnaldo F.
Moraes, Manoel Odorico de
Gonzaga-Silva, Lúcio Flávio
Keywords: Obstrução do Colo da Bexiga Urinária
Bexiga Urinária Hiperativa
Issue Date: Jul-2014
Publisher: International Brazilian Journal of Urology
Citation: REGADAS, R. P. et al. Effects of chronic administration of tamsulosin and tadalafil, alone or in combination, in rats with bladder outlet obstruction induced by chronic nitric oxide deficiency. International Brazilian Journal of Urology, Rio de Janeiro, v. 40, n. 4, p. 546-552, jul./ago., 2014.
Abstract: Purpose: The aim of this study was to define if tadalafil causes detrusor muscle impairment and to observe the effect of combination of tadalafil with tamsulosin on the lower urinary tract of rats with bladder outlet obstruction (BOO) induced by chronic nitric oxide deficiency. Materials and Methods: Thirty-one male rats were randomized to following groups: 1 - control; 2 - L-Nitroarginine methyl ester (L-NAME); 3 - Tamsulosin + L-NAME, 4 Tadalafil+L-NAME; and 5 - Tamsulosin + Tadalafil + L-NAME. At the end of the treatment period (30 days), all animals were submitted to urodynamic study. Results: The administration of L-NAME increased the number of non-voiding contractions (NVC) (1.04 ± 0.22), volume threshold (VT) (1.86 ± 0.35), and micturition cycle (MC) (1.34 ± 0.11) compared with control (0.52 ± 0.06, 0.62 ± 0.06, and 0.67 ± 0.30), respectively. The administration of tamsulosin reduced the number of NVC (0.57 ± 0.42) and VT (0.76 ± 0.24 ) compared with L-NAME group. Co-treatment with tadalafil decreased the number of VT (0.85 ± 0.53) and MC (0.76 ± 0.22) compared with L-NAME group. The combination of tamsulosin with tadalafil improved the number of NVC (0.56 ± 0.18), VT (0.97 ± 0.52) and MC (0.68 ± 0.30) compared with L-NAME group. Conclusion: In rats with BOO induced by chronic nitric oxide deficiency, tadalafil did not cause impairment in detrusor muscle and seems to have an addictive effect to tamsulosin because the combination decreased non voiding contractions as well the number of micturition cycles.
URI: http://www.repositorio.ufc.br/handle/riufc/11039
ISSN: 1677-5538 Impressa
Appears in Collections:DCIR - Artigos publicados em revista científica

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