Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/11238
Title in Portuguese: Anxiolytic-Like effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in mice
Author: MELO, Carla Thiciane Vasconcelos de
MONTEIRO, Andreisa Paiva
LEITE, Caroline Porto
ARAÚJO, Fernando Luiz Oliveira de
LIMA, Vera Targino Moreira
BARBOSA-FILHO, José Maria
VASCONCELOS, Silvânia Maria Mendes de
VIANA, Glauce Socorro de Barros
SOUSA, Francisca Cléa Florenço de
FONTELES, Marta Maria de França
Keywords: Ansiolíticos
Anti-Anxiety Agents
Issue Date: Mar-2006
Publisher: Biological & Pharmaceutical Bulletin
Citation: MELO, C. T. V. de. et al. Anxiolytic-Like effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in mice. Biological & Pharmaceutical Bulletin, Tokyo, v. 29, n.3, p. 451-454, mar. 2006.
Abstract: This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (NEES) MEZ (Lauraceae) in animal models of open field, rota rod, elevated plus maze and hole board tests in mice. Riparin III (ripIII) was administered orally, in male mice, at single doses of 25 and 50 mg/kg. The results showed that ripIII, at both doses, had no effects on the spontaneous motor activity in the rota rod test nor in the number of squares crossed in the open field test. However, riparin III decreased the number of grooming and rearing. In the plus maze test, ripIII, at both doses increased the following parameters: percentage of entries in the open arms (PEOA), time of permanence in the open arms (TPOA) and percentage of time of permanence in the open arms (PTOA) and at the dose of 50 mg/kg, increased the number of entries in the open arms (NEOA). Similarly, ripIII, at both doses, showed an increase in the number of head dips into the holes of the hole board test. These results show that riparin III presents anxiolytic effects in the plus maze and hole board tests which are not influenced by the locomotor activity in the open field test.
Description: MELO, C. T. V. de. et al. Anxiolytic-Like effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in mice. Biological & Pharmaceutical Bulletin, Tokyo, v. 29, n.3, p. 451-454, mar. 2006.
URI: http://www.repositorio.ufc.br/handle/riufc/11238
metadata.dc.type: Artigo de Periódico
ISSN: 1347-5215 On line
Appears in Collections:DFIFA - Artigos publicados em revista científica

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