Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/16584
Título: In vitro inhibitory activity of terpenic derivatives against clinical and environmental strains of the Sporothrix schenkii complex
Autor(es): Brilhante, Raimunda Sâmia Nogueira
Marques, Natalya Fechine Silva
Castelo-Branco, Débora de Souza Collares Maia
Lima, Rita Amanda Chaves de
Malaquias, Angela Donato Maia
Caetano, Erica Pacheco
Barbosa, Giovanna Riello
Camargo, Zoilo Pires de
Rodrigues, Anderson Messias
Monteiro, André Jalles
Bandeira, Tereza de Jesus Pinheiro Gomes
Cordeiro, Rossana de Aguiar
Sidrim, José Júlio Costa
Moreira, José Luciano Bezerra
Rocha, Marcos Fábio Gadelha
Silva, Natalya Fechine
Palavras-chave: Esporotricose
Iodeto de Potássio
Data do documento: 2015
Editor: Medical Mycology
Citação: BRILHANTE, R. S. N. ; SILVA, N. F. ; MARQUES, F. J. F. ; CASTELO-BRANCO, D. S. C. M. ; LIMA, R. A. C. ; MALAQUIAS, A. D. M. ; CAETANO, E. P. ; BARBOSA, G. R. ; CAMARGO, E. P. ; RODRIGUES, A. M. ; MONTEIRO, A. J. ; BANDEIRA, T. J. P. G. ; CORDEIRO, R. A. ; SIDRIM, J. J. C. ; MOREIRA, J. L. B. ; ROCHA, M. F. G. (2015)
Abstract: Sporotrichosis is a subacute or chronic subcutaneous infection, caused by the fungus Sporothrix schenkii complex, occurring in human and animal tissues. Potassium iodide and itraconazole have been used as effective therapy for first-choice treatment, while am- photericin B may be indicated for disseminated infection. However, the adverse effects of potassium iodide and amphotericin B or the long duration of therapy with itraconazole often weigh against their use, leading to the search for alternatives for the treatment of severe infections. Terpinen-4-ol and farnesol are components of essential oils present in many plant species and have been described to have antifungal activity against mi- croorganisms. In this study, 40 strains of Sporothrix spp. were tested for the suscep- tibility to terpinen-4-ol and farnesol. Changes in cytoplasmic membrane permeability were also investigated. Terpenes inhibited all Sporothrix strains with MIC values ranging from 87.9 to 1,429.8 μ g/ml for terpinen-4-ol and from 0.003 to 0.222 μ g/ml for farnesol. The MFC values ranged from 177.8 to 5,722.6 μ g/ml and from 0.027 to 0.88 μ g/ml, re- spectively, for terpinen-4-ol and farnesol. Farnesol was the most active compound for the Sporothrix strains. Significant loss of 260 and 280 nm-absorbing material did not occur after treatment with concentrations equivalent to the MIC and sub-MIC of the tested ter- penes, when compared to corresponding untreated samples. The failure of terpenes to lyse Sporothrix cells suggests that their primary mechanism of action is not by causing irreversible cell membrane damage. Thus, new studies are needed to better understand the mechanisms involved in the antifungal activity.
Descrição: BRILHANTE, Raimunda Samia Nogueira ; SILVA, Natalya Fechine ; MARQUES, Francisca Jakelyne de Farias ; CASTELO-BRANCO, Debora de Souza Collares Maia ; LIMA ; Rita Amanda Chaves de ; MALAQUIAS, Angela Donato Maia ; CAETANO, Erica Pacheco ; BARBOSA, Giovanna Riello ; CAMARGO, Zoilo Pires de ; RODRIGUES, Anderson Messias ; MONTEIRO, Andre Jalles ; BANDEIRA, Tereza de Jesus Pinheiro Gomes ; CORDEIRO, Rossana de Aguiar ; SIDRIM, José Júlio Costa ; MOREIRA, José Luciano Bezerra ; ROCHA, Marcos Fábio Gadelha. In vitro inhibitory activity of terpenic derivatives against clinical and environmental strains of the Sporothrix schenkii complex. Medical Mycology, Oxford, v. 53, p. 93-98, 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/16584
ISSN: 1369-3786
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