Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/16825
Título: The resin from protium heptaphyllum prevents high-fat diet-induced obesity in mice : scientific evidence and potential mechanisms
Autor(es): Carvalho, Karine Maria Martins Bezerra
MarinhoFilho, José Delano Barreto
Melo, Tiago Sousa de
Araújo, Ana Jérsia
Quetz, Josiane da Silva
Cunha, Mariado Perpétuo Socorro Saldanha da
Melo, Karina Moura de
Silva, Armenio Andrede Carvalho Almeida da
Tomé, Adriana Rocha
Havt, Alexandre
Fonseca, Said Gonçalves da Cruz
Brito, Gerly Annede Castro
Chaves, Mariana Helena
Rao, Vietla Satyanarayana
Santos, Flávia Almeida
Palavras-chave: Dieta
Obesidade
Data do documento: Jan-2015
Editor: Evidence-Based Complementary and Alternative Medicine
Citação: CARVALHO, K. M. M. B. ; MARINHO FILHO, J. D. B. ; MELO, T. S. ; ARAÚJO, A. J. ; QUETZ, J. S. ; CUNHA, M. P. S. S. ; MELO, K. M. ; SILVA, A. A. C. A. ; TOMÉ, A. R. ; HAVT, A. ; FONSECA, S. G. C. ; BRITO, G. A. C. ; CHAVES, M. H. ; RAO, V. S. SANTOS, F. A. (2015)
Abstract: Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolicdisorders.ThepresentstudyinvestigatedtheantiobesitypropertiesofresinfromProtiumheptaphyllum(RPH)andthe possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, netenergyintake,abdominalfataccumulation,plasmaglucose,amylase,lipase,triglycerides,andtotalcholesterolrelativetotheir respectivecontrols,whichwereRPHunfed.Additionally,RPHtreatment,whilesignificantlyelevatingtheplasmalevelofghrelin hormone,decreasedthelevelsofinsulin,leptin,andresistin.Besides,HFD-inducedincreasesinplasmalevelsofproinflammatory mediators TNF-𝛼, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore, in vitro studies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50𝜇g/mL.ThesefindingssuggestthattheantiobesepotentialofRPHislargelyduetoitsmodulatoryeffectsonvarioushormonal andenzymaticsecretionsrelatedtofatandcarbohydratemetabolismandtotheregulationofobesity-associatedinflammation.
Descrição: CARVALHO, Karine Maria Martins Bezerra ; MARINHO FILHO, José Delano Barreto ; MELO, Tiago Sousa de ; ARAÚJO, Ana Jérsia ; QUETZ, Josiane da Silva ; CUNHA, Maria do Perpétuo Socorro Saldanha ; MELO, Karina Moura de ; SILVA, Armenio Andre de Carvalho Almeida da ; TOMÉ, Adriana Rocha ; HAVT, Alexandre ; FONSECA, Said Gonçalves da Cruz ; BRITO, Gerly Anne de Castro ; CHAVES, Mariana Helena ; RAO, Vietla Satyanarayana ; SANTOS, Flávia almeida . The resin from protium heptaphyllum prevents high-fat diet-induced obesity in mice : scientific evidence and potential mechanisms. Evidence-Based Complementary and Alternative Medicine, v. 2015, p. 1-13, jan. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/16825
ISSN: 1741-427X
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