Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/17739
Title in Portuguese: Postoperative hemostatic efficacy of gauze soaked in tranexamic acid, fibrin sponge, and dry gauze compression following dental extractions in anticoagulated patients with cardiovascular disease : a prospective, randomized study
Author: Soares, Eduardo Costa Studart
Costa, Fábio Wildson Gurgel
Bezerra, Tácio Pinheiro
Nogueira, Carlos Bruno Pinheiro
Silva, Paulo Goberlânio de Barros
Batista, Saulo Hilton Botelho
Sousa, Fabrício Bitu
Fonteles, Cristiane Sá Roriz
Keywords: Cirurgia Oral
Hemostasia
Anticoagulantes
Issue Date: 2015
Publisher: Oral and Maxillofacial Surgery
Citation: SOARES, E. C. S. et al. Postoperative hemostatic efficacy of gauze soaked in tranexamic acid, fibrin sponge, and dry gauze compression following dental extractions in anticoagulated patients with cardiovascular disease : a prospective, randomized study. Oral and Maxillofacial Surgery, v. 19, p. 209-216, 2015.
Abstract: Introduction Oral anticoagulants are widely prescribed drugs. Interruption of anticoagulant therapy prior to oral surgery has been an issue of great controversy. The purpose of this study was to evaluate the incidence of bleeding complications after dental extractions in patients on anticoagulant therapy (warfarin) in whom different local hemostatic methods were used. Material and methods Patients using warfarin and requiring extractions of at least two teeth were screened to participate in this prospective, randomized study. Extraction sites were con- sidered as sampling units (statistically representative sample size) and were allocated to one of the three study groups (G1 — 4.8 % tranexamic acid; G2 — fibrin sponge; and G3 — no local hemostatic agents). Results Eighty-four extraction sites were obtained from pa- tients with mitral valve prolapse (47.4 %), prosthetic cardiac valve (23.7 %), venous thromboembolism (21.1 %), and pulmonary embolism (5.2 %). International normalized ratio (INR) values ranged between 2.1 and 3.1 (mean 2.51±0.1). Postoperative bleeding was observed in four surgical sites ( p <0.001) and was mainly in older patients ( p =0.005). Discussion The three local hemostatic protocols were similar- ly effective in controlling postoperative bleeding in patients undergoing anticoagulant therapy with warfarin. The majority of teeth could be extracted with minimal problems in patients with cardiovascular diseases receiving treatment with antico- agulant therapy.
URI: http://www.repositorio.ufc.br/handle/riufc/17739
metadata.dc.type: Artigo de Periódico
ISSN: 1865-1550
Appears in Collections:DCOD - Artigos publicados em revistas científicas

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