Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/17780
Título: Preconditioning with mono and polyunsaturated fatty acids and low-intensity electrical stimulation. Effects on skin repair in rats
Autor(es): Cardoso, Maria dos Prazeres Carneiro
Albuquerque, Andréa de Oliveira
Girão, Virginia Claudia Carneiro
Pompeu, Margarida Maria de Lima
Silva, Cícero Igor Simões Moura
Azevedo, Orleâncio Gomes Ripardo de
Guimarães, Sergio Botelho
Vasconcelos, Paulo Roberto Leitão de
Palavras-chave: Óleos
Cicatrização
Pele
Data do documento: Fev-2015
Editor: Acta Cirúrgica Brasileira
Citação: CARDOSO, M. P. C. ; ALBUQUERQUE, A. O. ; GIRÃO, V. C. C. ; POMPEU, M. M. L. ; SILVA, C. I. S. M. ; AZEVEDO, O. G. R. ; GUIMARÃES, S. B. ; VASCONCELOS, P. R. L. (2015)
Abstract: PURPOSE: To evaluate the effects of preconditioning with oils mixes containing ω3/ω6/ω9 associated with micro-currents on skin repair in rats. METHODS: One-hundred and eight Wistar rats randomized into G-1, G-2 and G-3 groups were treated with saline (0.9%), mix 1 (corn+soybean oils) and mix 2 (olive+canola+flaxseed oils), respectively, in a single dose (0.01ml/g) by gavage. Next, each group was subdivided into sham and stimulated subgroups. Pulsed-wave microcurrents (0.5 µA, 0.5 Hz) were applied to stimulated subgroups for 20 min. One hour later anesthetized rats were subjected to surgery. A dorsal incision (6 cm long) was carried out and closed with interrupted nylon sutures. Samples (1cm2) were harvested from the mid-portion of the incision on the 7, 14, 21 post-operative (P.O.) days. Variables were analyzed using Mann-Whitney/Dunn tests Significance level was set to 5 % (p<0.05). RESULTS: Micro-currents promoted increase of exudate and reduction of epithelialization on day 7 in G1 rats. Mixes 1/2 reduced vascularization on 7/14th days P.O. Both 1/2 mixes reduced fibrosis on day 14. Preconditioning with mix 1 led to increased expression of NF-kB on the 7th day. CONCLUSION: Preconditioning with microcurrents has pro-inflammatory effects while oil mixes 1 and 2 decrease fibrosis and vascularization in the proliferative phase of cicatrization.
Descrição: CARDOSO, Maria dos Prazeres Carneiro ; ALBUQUERQUE, Andréa de Oliveira ; GIRÃO, Virginia Claudia Carneiro ; POMPEU, Margarida Maria de Lima ; SILVA, Cícero Igor Simões Moura ; AZEVEDO, Orleâncio Gomes Ripardo de ; GUIMARÃES, Sergio Botelho ; VASCONCELO, Paulo Roberto Leitão de. Preconditioning with mono and polyunsaturated fatty acids and low-intensity electrical stimulation. Effects on skin repair in rats. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 2, p. 107-114, feb. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/17780
ISSN: 1678-2674 On-line
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