Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/17907
Título: Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus species
Autor(es): Brilhante, Raimunda Sâmia Nogueira
Caetano, Erica Pacheco
Oliveira, Jonathas Sales de
Castelo-Branco, Débora de Souza Collares Maia
Souza, Elizabeth Ribeiro Yokobatake
Alencar, Lucas Pereira de
Cordeiro, Rossana de Aguiar
Bandeira, Tereza de Jesus Pinheiro Gomes
Sidrim, José Júlio Costa
Rocha, Marcos Fábio Gadelha
Palavras-chave: Candida
Cryptococcus
Sinvastatina
Data do documento: Set-2015
Editor: The Brazilian Journal of Infectious Diseases
Citação: BRILHANTE, R. S. N. ; CAETANO, E. P. ; OLIVEIRA, J. S. ; CASTELO-BRANCO, D. S. C. M. ; SOUZA, E. R. Y. ; ALENCAR, L. P. ; CORDEIRO, R. A. ; BANDEIRA, T. J. P. G. ; SIDRIM, J. J. C. ; ROCHA, M. F. G. (2015)
Abstract: The antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested against Candida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against planktonic growth and tested against biofilms of Candida spp. and Cryptococcus spp. Drug susceptibility testing was performed using the microdilution broth method, as described by the Clinical and Laboratory Standards Institute. The interaction between simvastatin and antifungals against planktonic cells was analyzed by calculating the fractional inhibitory concentration index. Regarding biofilm susceptibility, simvastatin was tested against growing biofilm and mature biofilm of one strain of each tested yeast species. Simvastatin showed inhibitory effect against Candida spp. and Cryptococcus spp. with minimum inhibitory concentration values ranging from 15.6 to 1000 mg L−1 and from 62.5 to 1000 mg L−1, respectively. The combination of simvastatin with itraconazole and fluconazole showed synergism against Candida spp. and Cryptococcus spp., while the combination of simvastatin with amphotericin B was synergistic only against Cryptococcus spp. Concerning the biofilm assays, simvastatin was able to inhibit both growing biofilm and mature biofilm of Candida spp. and Cryptococcus spp. The present study showed that simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus species.
Descrição: BRILHANETE, Raimunda Sâmia Nogueira et al. Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus species. The Brazilian Journal of Infectious Diseases, Salvador, v. 19, n. 5, p. 459-465, sep./oct. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/17907
ISSN: 1413-8670
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